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Titolo:
Identifying rate-limiting nodes in large-scale cortical networks for visuospatial processing: An illustration using fMRI
Autore:
Ng, VWK; Bullmore, ET; de Zubicaray, GI; Cooper, A; Suckling, J; Williams, SCR;
Indirizzi:
Univ London Kings Coll, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Guys Kings & St Thomass Med Sch, London, England Guys Kings & St Thomass Med Sch London England Med Sch, London, England Univ Queensland, St Lucia, Qld 4067, Australia Univ Queensland St Lucia Qld Australia 4067 St Lucia, Qld 4067, Australia Univ Cambridge, Cambridge CB2 1TN, England Univ Cambridge Cambridge England CB2 1TN dge, Cambridge CB2 1TN, England
Titolo Testata:
JOURNAL OF COGNITIVE NEUROSCIENCE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 537 - 545
SICI:
0898-929X(200105)13:4<537:IRNILC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERIC BRAIN ACTIVATION; MENTAL ROTATION; FUNCTIONAL ACTIVATION; IMAGE-ANALYSIS; BLOOD-FLOW; DISCRIMINATION; ORIENTATION; JUDGMENT; PATHWAY; OBJECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ng, VWK Maudsley Hosp, Denmark Hill, London SE5 8AZ, England Maudsley HospDenmark Hill London England SE5 8AZ E5 8AZ, England
Citazione:
V.W.K. Ng et al., "Identifying rate-limiting nodes in large-scale cortical networks for visuospatial processing: An illustration using fMRI", J COGN NEUR, 13(4), 2001, pp. 537-545

Abstract

With the advent of functional neuroimaging techniques, in particular functional magnetic resonance imaging (fMRI), we have gained greater insight into the neural correlates of visuospatial function. However, it may not always be easy to identify the cerebral regions most specifically associated with performance on a given task. One approach is to examine the quantitative relationships between regional activation and behavioral performance measures. In the present study, we investigated the functional neuroanatomy of two different visuospatial processing tasks, judgement of line orientation and mental rotation. Twenty-four normal participants were scanned with fMRI using blocked periodic designs for experimental task presentation. Accuracy and reaction time (RT) to each trial of both activation and baseline conditions in each experiment was recorded. Both experiments activated dorsal andventral visual cortical areas as well as dorsolateral prefrontal cortex. More regionally specific associations with task performance were identified by estimating the association between (sinusoidal) power of functional response and mean RT to the activation condition; a permutation test based on spatial statistics was used for inference. There was significant behavioral-physiological association in right ventral extrastriate cortex for the lineorientation task and in bilateral (predominantly right) superior parietal lobule for the mental rotation task. Comparable associations were not foundbetween power of response and RT to the baseline conditions of the tasks. These data suggest that one region in a neurocognitive network may be most strongly associated with behavioral performance and this may be regarded asthe computationally least efficient or rate-limiting node of the network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 03:55:09