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Titolo:
Structural organization and regulation of the small proline-rich family ofcornified envelope precursors suggest a role in adaptive barrier function
Autore:
Cabral, A; Voskamp, P; Cleton-Jansen, AM; South, A; Nizetic, D; Backendorf, C;
Indirizzi:
Leiden Inst Chem, Dept Mol Genet, NL-2300 RA Leiden, Netherlands Leiden Inst Chem Leiden Netherlands NL-2300 RA 00 RA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Univ London, Sch Pharm, Ctr Appl Mol Biol, London WC1N 1AX, England Univ London London England WC1N 1AX l Mol Biol, London WC1N 1AX, England
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 22, volume: 276, anno: 2001,
pagine: 19231 - 19237
SICI:
0021-9258(20010601)276:22<19231:SOAROT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN EPIDERMAL-KERATINOCYTES; TRANSGLUTAMINASE SUBSTRATE PROPERTIES; STRATIFIED SQUAMOUS EPITHELIA; HUMAN-CHROMOSOME 1Q21; CELL-ENVELOPE; DIFFERENTIATION COMPLEX; TERMINAL DIFFERENTIATION; RETINOIC ACID; EXPRESSION; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Backendorf, C Gorlaeus Labs, Mol Genet Lab, POB 9502, NL-2300 RA Leiden, Netherlands Gorlaeus Labs POB 9502 Leiden Netherlands NL-2300 RA rlands
Citazione:
A. Cabral et al., "Structural organization and regulation of the small proline-rich family ofcornified envelope precursors suggest a role in adaptive barrier function", J BIOL CHEM, 276(22), 2001, pp. 19231-19237

Abstract

The protective barrier provided by stratified squamous epithelia relies onthe cornified cell envelope (CE), a structure synthesized at late stages of keratinocyte differentiation. It is composed of structural proteins, including involucrin, loricrin, and the small proline-rich (SPRR) proteins, allencoded by genes localized at human chromosome 1q21, The genetic characterization of the SPRR locus reveals that the various members of this multigene family can be classified into two distinct groups with separate evolutionary histories. Whereas group 1 genes have diverged in protein structure andare composed of three different classes (SPRR1 (2x), SPRR3, and SPRR4), anactive process of gene conversion has counteracted diversification of the protein sequences of group 2 genes (SPRR2 class, seven genes). Contrasting with this homogenization process, all individual members of the SPRR gene family show specific in vivo and in vitro expression patterns and react selectively to UV irradiation. Apparently, creation of regulatory rather than structural diversity has been the driving force behind the evolution of the SPRR gene family. Differential regulation of highly homologous genes underlines the importance of SPRR protein dosage in providing optimal barrier function to different epithelia, while allowing adaptation to diverse externalinsults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:28:02