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Titolo:
Physiological and genomic consequences of intermittent hypoxia - Selected contribution: Pulmonary hypertension in mice following intermittent hypoxia
Autore:
Fagan, KA;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Div Pulm Sci & Crit Care Med, Cardiovasc PulmRes Lab, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 ovasc PulmRes Lab, Denver, CO 80262 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2502 - 2507
SICI:
8750-7587(200106)90:6<2502:PAGCOI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE SLEEP-APNEA; RIGHT-VENTRICULAR HYPERTROPHY; SYSTEMIC BLOOD-PRESSURE; CHRONIC EPISODIC HYPOXIA; INDUCIBLE FACTOR 1-ALPHA; TRANSGENIC MICE; HIGH-ALTITUDE; RATS; SYNTHASE; EXPRESSION;
Keywords:
sleep apnea; vascular remodeling; polycythemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Fagan, KA 4200 E 9th Ave,B-133, Denver, CO 80262 USA 4200 E 9th Ave,B-133Denver CO USA 80262 , Denver, CO 80262 USA
Citazione:
K.A. Fagan, "Physiological and genomic consequences of intermittent hypoxia - Selected contribution: Pulmonary hypertension in mice following intermittent hypoxia", J APP PHYSL, 90(6), 2001, pp. 2502-2507

Abstract

Sleep apnea (intermittent periods of hypoxia with or without hypercapnia) is associated with systemic hypertension and increased mortality from cardiovascular disease, but the relationship to pulmonary hypertension is uncertain. Previous studies on intermittent hypoxia (IH) in rats that demonstrated pulmonary hypertension utilized relatively long periods of hypoxia. Recent studies that utilized brief periods of hypoxia have conflicting reports of right ventricular (RV) hypertrophy. In addition, many studies have not measured pulmonary hemodynamics to asses the severity of pulmonary hypertension in vivo. Given the increasing availability of genetically engineered mice and the need to establish a rodent model of IH-induced pulmonary hypertension, we studied the effect of IH (2-min cycles of 10% and 21% O-2, 8 h/day, 4 wk) on wild-type mice, correlating in vivo measurements of pulmonary hypertension with RV mass and pulmonary vascular remodeling. RV systolic pressure was increased after IH (36 +/- 0.9 mmHg) compared with normoxia (29.5 /- 0.6) but was lower than continuous hypoxia (44.2 +/- 3.4). RV mass [RV-to-( left ventricle plus septum) ratio] correlated with pressure measurements (IH = 0.27 +/- 0.02, normoxia = 0.22 +/- 0.01, and continuous hypoxia = 0.34 +/- 0.01). Hematocrits were also elevated after IH and continuous hypoxia (56 +/- 1.6 and 54 +/- 1.1 vs. 44.3 +/- 0.5%). Evidence of neomuscularization of the distal pulmonary circulation was found after IH and continuous hypoxia. We conclude that mice develop pulmonary hypertension following IH, representing a possible animal model of pulmonary hypertension in response to the repetitive hypoxia-reoxygenation of sleep apnea.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:30:36