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Titolo:
Physiological and genomic consequences of intermittent hypoxia - Selected Contribution: Regulation of sleep-wake states in response to intermittent hypoxic stimuli applied only in sleep
Autore:
Hamrahi, H; Stephenson, R; Mahamed, S; Liao, KS; Horner, RL;
Indirizzi:
Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 t Med, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 ysiol, Toronto, ON M5S 1A8, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2490 - 2501
SICI:
8750-7587(200106)90:6<2490:PAGCOI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE-MOVEMENT SLEEP; REM-SLEEP; AUTOMOBILE ACCIDENTS; EPISODIC HYPOXIA; DENERVATED RATS; BLOOD-PRESSURE; APNEA; TEMPERATURE; HUMANS; PERFORMANCE;
Keywords:
rats; obstructive sleep apnea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Horner, RL Rm 6368 Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Rm 6368 Med Sci Bldg,1 Kings Coll Circle Toronto ON Canada M5S 1A8
Citazione:
H. Hamrahi et al., "Physiological and genomic consequences of intermittent hypoxia - Selected Contribution: Regulation of sleep-wake states in response to intermittent hypoxic stimuli applied only in sleep", J APP PHYSL, 90(6), 2001, pp. 2490-2501

Abstract

Recurrent sleep-related hypoxia occurs in common disorders such as obstructive sleep apnea (OSA). The marked changes in sleep after treatment suggestthat stimuli associated with OSA (e.g., intermittent hypoxia) may significantly modulate sleep regulation. However, no studies have investigated the independent effects of intermittent sleep-related hypoxia on sleep regulation and recovery sleep after removal of intermittent hypoxia. Ten rats were implanted with telemetry units to record the electroencephalogram (EEG), neck electromyogram, and body temperature. After >7 days recovery, a computeralgorithm detected sleep-wake states and triggered hypoxic stimuli (10% O-2) or room air stimuli only during sleep for a 3-h period. Sleep-wake states were also recorded for a 3-h recovery period after the stimuli. Each rat received an average of 69.0 +/- 6.9 hypoxic stimuli during sleep. The non-rapid eye movement (non-REM) and rapid-eye-movement (REM) sleep episodes averaged 50.1 +/- 3.2 and 58.9 +/- 6.6 s, respectively, with the hypoxic stimuli, with 32.3 +/- 3.2 and 58.6 +/- 4.8 s of these periods being spent in hypoxia. Compared with results for room air controls, hypoxic stimuli led to increased wakefulness (P< 0.005), nonsignificant changes in non-REM sleep, and reduced REM sleep (P< 0.001). With hypoxic stimuli, wakefulness episodes were longer and more frequent, non-REM periods were shorter and more frequent, and REM episodes were shorter and less frequent (P< 0.015). Hypoxic stimuli also increased faster frequencies in the EEG (P< 0.005). These effects of hypoxic stimuli were reversed on return to room air. There was a rebound increase in REM sleep, increased slower non-REM EEG frequencies, and decreased wakefulness (P< 0.001). The results show that sleep-specific hypoxia leads to significant modulation of sleep-wake regulation both during and after application of the intermittent hypoxic stimuli. This study is the first to determine the independent effects of sleep-related hypoxia on sleep regulation that approximates OSA before and after treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:55:40