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Titolo:
Physiological and genomic consequences of intermittent hypoxia - Invited Review: Adaptive responses of skeletal muscle to intermittent hypoxia: the known and the unknown
Autore:
Clanton, TL; Klawitter, PF;
Indirizzi:
Ohio State Univ, Dorothy Davis Heart & Lung Inst, Dept Internal Med, Div Pulm & Crit Care, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 & Crit Care, Columbus, OH 43210 USA Ohio State Univ, Dorothy Davis Heart & Lung Inst, Dept Emergency Med, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ergency Med, Columbus, OH 43210 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2476 - 2487
SICI:
8750-7587(200106)90:6<2476:PAGCOI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE SLEEP-APNEA; PERIPHERAL ARTERIAL INSUFFICIENCY; HIGH-ALTITUDE HYPOXIA; OPERATION EVEREST-II; VEGF GENE-EXPRESSION; MYOSIN HEAVY-CHAIN; K-ATP CHANNEL; REACTIVE OXYGEN; ENERGY-METABOLISM; SYMPATHETIC ACTIVITY;
Keywords:
altitude; ion transport; preconditioning; antioxidant; free radicals; reactive oxygen; obstructive sleep apnea; peripheral vascular occlusive disease; citrate synthase; cytochrome oxidase; myosin heavy chain;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Clanton, TL Ohio State Univ, Dorothy Davis Heart & Lung Inst, Dept Internal Med, Div Pulm & Crit Care, 201,472 W 12th, Columbus, OH 43210 USA Ohio State Univ 201,472 W 12th Columbus OH USA 43210 43210 USA
Citazione:
T.L. Clanton e P.F. Klawitter, "Physiological and genomic consequences of intermittent hypoxia - Invited Review: Adaptive responses of skeletal muscle to intermittent hypoxia: the known and the unknown", J APP PHYSL, 90(6), 2001, pp. 2476-2487

Abstract

Intermittent hypoxia (IH) describes conditions of repeated, transient reductions in O-2 that may trigger unique adaptations. Rest periods during IH may avoid potentially detrimental effects of long-term O-2 deprivation. For skeletal muscle, IH can occur in conditions of obstructive sleep apnea, transient altitude exposures (with or without exercise), intermittent claudication, cardiopulmonary resuscitation, neonatal blood flow obstruction, and diving responses of marine animals. Although it is likely that adaptations in these conditions vary, some patterns emerge. Low levels of hypoxia shift metabolic enzyme activity toward greater aerobic poise; extreme hypoxia shifts metabolism toward greater anaerobic potential. Some conditions of IH may also inhibit lactate release during exercise. Many related cellular phenomena could be involved in the response, including activation of specific O-2 sensors, reactive oxygen and nitrogen species, preconditioning, hypoxia-induced transcription factors, regulation of ion channels, and influences ofparacrine/ hormonal stimuli. The net effect of a variety of adaptive programs to IH may be to preserve contractile function and cell integrity in hypoxia or anoxia, a response that does not always translate into improvementsin exercise performance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 08:40:27