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Titolo:
Relationship between myosin phosphorylation and contractile capability of canine airway smooth muscle
Autore:
Mitchell, RW; Seow, CY; Burdyga, T; Mass-Moreno, R; Pratusevich, VR; Ragozzino, J; Ford, LE;
Indirizzi:
Indiana Univ, Sch Med, Dept Med, Krannert Inst Cardiol, Indianapolis, IN 46223 USA Indiana Univ Indianapolis IN USA 46223 ardiol, Indianapolis, IN 46223 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2460 - 2465
SICI:
8750-7587(200106)90:6<2460:RBMPAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT CHAIN PHOSPHORYLATION; SHORTENING VELOCITY; FORCE; PLASTICITY;
Keywords:
tracheal smooth muscle; force-velocity relations; activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ford, LE Indiana Univ, Sch Med, Dept Med, Krannert Inst Cardiol, Indianapolis, IN 46223 USA Indiana Univ Indianapolis IN USA 46223 ndianapolis, IN 46223 USA
Citazione:
R.W. Mitchell et al., "Relationship between myosin phosphorylation and contractile capability of canine airway smooth muscle", J APP PHYSL, 90(6), 2001, pp. 2460-2465

Abstract

To better understand excitation-contraction coupling in smooth muscle, myosin phosphorylation and force-velocity properties of canine tracheal musclewere compared during the rise and early plateau of force in electrically stimulated tetani. Velocity reached a peak of similar to1.5 times plateau value when force had risen to similar to 45% of its maximum value and then declined progressively. Except early in the tetanus, when phosphorylation rose rapidly, maximum power and phosphorylation had nearly parallel time courses, reaching peaks of 1.2-1.3 times reference at 6-8 s before declining to the plateau level at similar to 12 s. Force, velocity, maximum power, and phosphorylation fell somewhat during the plateau, with the closest correlation between phosphorylation and power. These results suggest that 1) early velocity slowing is not associated with light chain dephosphorylation and 2)maximum power, which we use to signal changes in activation, is closely correlated with the degree of light chain phosphorylation, at least when phosphorylation level is not changing rapidly. Dissociation of these two properties would be expected early in the tetanus if phosphorylation precedes mechanical activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:08:45