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Titolo:
Long-term effect of low energy laser irradiation on infarction and reperfusion injury in the rat heart
Autore:
Yaakobi, T; Shoshany, Y; Levkovitz, S; Rubin, O; Ben Haim, SA; Oron, U;
Indirizzi:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 t Zool, IL-69978 Tel Aviv, Israel Technion Israel Inst Technol, Fac Med, IL-34362 Haifa, Israel Technion Israel Inst Technol Haifa Israel IL-34362 L-34362 Haifa, Israel
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2411 - 2419
SICI:
8750-7587(200106)90:6<2411:LEOLEL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOAD BUFO-VIRIDIS; GASTROCNEMIUS-MUSCLE; MYOCARDIAL-INFARCTION; REGENERATION; ANGIOGENESIS; ENHANCEMENT; FIBROBLASTS; MECHANISMS; ISCHEMIA; PROTEIN;
Keywords:
ischemia; myocardial infarction; angiogenesis; heat shock proteins; laser;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Oron, U Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, IL-69978 TelAviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 IL-69978 Tel Aviv, Israel
Citazione:
T. Yaakobi et al., "Long-term effect of low energy laser irradiation on infarction and reperfusion injury in the rat heart", J APP PHYSL, 90(6), 2001, pp. 2411-2419

Abstract

Low-energy laser irradiation (LELI) has been found to modulate biological processes. The present study investigated the effect of LELI on infarct size after chronic myocardial infarction (MI) and ischemia-reperfusion injury in rats. The left anterior descending (LAD) coronary artery was ligated in 83 rats to create MI or ischemia-reperfusion injury. The hearts of the laser-irradiated (LI) rats received irradiation after LAD coronary artery occlusion and 3 days post-MI. At 14, 21, and 45 days post-LAD coronary artery permanent occlusion, infarct sizes (percentage of left ventricular volume) inthe non-laser-irradiated (NLI) rats were 52 +/- 12 (SD), 47 +/- 11, and 34+/- 7%, respectively, whereas in the LI rats they were significantly lower, being 20 +/- 8, 15 +/- 6, and 10 +/- 4%, respectively. Left ventricular dilatation (LVD) in the chronic infarcted rats was significantly reduced (50-60%) in LI compared with NLI rats. LVD in the ischemia-reperfusion-injuredLI rats was significantly reduced to a value that did not differ from intact normal noninfarcted rats. Laser irradiation caused a significant 2.2-fold elevation in the content of inducible heat shock proteins (specifically HSP70i) and 3.1-fold elevation in newly formed blood vessels in the heart compared with NLI rats. It is concluded that LELI caused a profound reductionin infarct size and LVD in the rat heart after chronic MI and caused complete reduction of LVD in ischemic-reperfused heart. This phenomenon may be partially explained by the cardioprotective effect of the HSP70i and enhanced angiogenesis in the myocardium after laser irradiation.

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Documento generato il 25/01/20 alle ore 07:06:54