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Titolo:
Glutamine induces heat shock protein and protects against endotoxin shock in the rat
Autore:
Wischmeyer, PE; Kahana, M; Wolfson, R; Ren, HY; Musch, MM; Chang, EB;
Indirizzi:
Univ Chicago, Dept Med, Martin Boyer Labs, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 artin Boyer Labs, Chicago, IL 60637 USA Univ Chicago, Dept Pediat, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ago, Dept Pediat, Chicago, IL 60637 USA Univ Chicago, Dept Anesthesia & Crit Care, Div Pediat, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Care, Div Pediat, Chicago, IL 60637 USA Univ Chicago, Div Clin Pharmacol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 v Clin Pharmacol, Chicago, IL 60637 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2403 - 2410
SICI:
8750-7587(200106)90:6<2403:GIHSPA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERIAL TRANSLOCATION; PARENTERAL-NUTRITION; AMINO-ACIDS; SEPSIS; INJURY; CELLS; PATHOGENESIS; METABOLISM; INDUCTION; SURVIVAL;
Keywords:
amino acid; organ injury; sepsis; animal model; stress proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, EB Univ Chicago, Dept Med, Martin Boyer Labs, 5841 S Maryland Ave, Chicago, IL 60637 USA Univ Chicago 5841 S Maryland Ave Chicago IL USA 60637 60637 USA
Citazione:
P.E. Wischmeyer et al., "Glutamine induces heat shock protein and protects against endotoxin shock in the rat", J APP PHYSL, 90(6), 2001, pp. 2403-2410

Abstract

Enhanced expression of heat shock protein (HSP) has been shown to be protective against laboratory models of septic shock. Induction of HSPs to improve outcome in human disease has not been exploited because laboratory induction agents are themselves toxic and not clinically relevant. In this study, we demonstrate that a single dose of intravenous glutamine causes a rapidand significant increase in HSP25 and HSP72 expression in multiple organs of the unstressed Sprague-Dawley rat. With the utilization of a fluid-resuscitated rat model of endotoxemia, mortality was dramatically reduced by glutamine administration concomitant with the endotoxin injury. Endotoxin-treated animals given glutamine exhibited dramatic increases in tissue HSP expression and marked reduction of end-organ damage. These data suggest glutamine may protect against mortality and attenuate end-organ injury in endotoxemic shock via enhanced HSP expression. Furthermore, glutamine confers protection when administered at the initiation of sepsis, rather than as pretreatment. Thus glutamine appears to be a clinically viable enhancer of HSP expression and may prove beneficial in the therapy of sepsis and sepsis-induced organ injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:39:35