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Titolo:
Role of vagal C-fiber afferents in the bronchomotor response to lactic acid in the newborn dog
Autore:
Marantz, MJ; Vincent, SG; Fisher, JT;
Indirizzi:
Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 siol, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Paediat, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 diat, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Anaesthesiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 siol, Kingston, ON K7L 3N6, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2311 - 2318
SICI:
8750-7587(200106)90:6<2311:ROVCAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREATHING PATTERN; NERVE-FIBERS; BRONCHOCONSTRICTION; INNERVATION; TACHYKININ; AIRWAYS; CAT;
Keywords:
lung C fiber; capsaicin; vanilloid receptor; vagus nerve; prostaglandin; bronchopulmonary dysplasia; autonomic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Fisher, JT Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 ton, ON K7L 3N6, Canada
Citazione:
M.J. Marantz et al., "Role of vagal C-fiber afferents in the bronchomotor response to lactic acid in the newborn dog", J APP PHYSL, 90(6), 2001, pp. 2311-2318

Abstract

We addressed the hypothesis that vagal C-fiber afferents and cyclooxygenase products are the mechanisms responsible for lactic acid (LA)-induced bronchoconstriction in the newborn dog. Perineural capsaicin and indomethacin were used to block conduction of vagal C fibers and production of cyclooxygenase products, respectively. Perineural capsaicin eliminated (85%) the increase in lung resistance (R-L; 45 +/- 5.6%) due to capsaicin (25 mug/kg), whereas the increase in RL (54 +/- 6.9%) due to LA (0.4 mmol/kg) was only inhibited by 37 +/- 4.7% (P < 0.05). Atropine reduced LA-induced bronchoconstriction (42 +/- 2.1%) by an amount similar to that obtained with perineural capsaicin. However, inhibition was significantly increased when atropine was combined with indomethacin (61 +/- 2.7%; P < 0.05), implicating cyclooxygenase products in the LA-induced bronchoconstrictor response. We conclude that the mechanisms responsible for LA-induced bronchoconstriction in the newborn are 1) activation of vagal C-fibers, which, through projections to medullary respiratory centers, leads to activation of vagal cholinergic efferents; 2) production of cyclooxygenase products, which cause bronchoconstriction independent of medullary involvement; and 3) an unknown bronchoconstrictor mechanism, putatively tachykinin mediated. On the basis of our data, pharmaceutical targeting of pulmonary afferents would prevent multiple downstream mechanisms that lead to airway narrowing due to inflammatory lung disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:53:59