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Titolo:
Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy
Autore:
Beauchamp, MH; Martinez-Bermudez, AK; Gobeil, F; Marrache, AM; Hou, X; Speranza, G; Abran, D; Quiniou, C; Lachapelle, P; Roberts, J; Almazan, G; Varma, DR; Chemtob, S;
Indirizzi:
Hop St Justine, Res Ctr, Dept Pediat, Montreal, PQ H3T 1C5, Canada Hop St Justine Montreal PQ Canada H3T 1C5 t, Montreal, PQ H3T 1C5, Canada Hop St Justine, Dept Ophthalmol, Montreal, PQ H3T 1C5, Canada Hop St Justine Montreal PQ Canada H3T 1C5 l, Montreal, PQ H3T 1C5, Canada Hop St Justine, Dept Pharmacol, Montreal, PQ H3T 1C5, Canada Hop St Justine Montreal PQ Canada H3T 1C5 l, Montreal, PQ H3T 1C5, Canada McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 peut, Montreal, PQ H3G 1Y6, Canada McGill Univ, Dept Ophthalmol, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 lmol, Montreal, PQ H3G 1Y6, Canada Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dept Med, Nashville, TN 37232 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2279 - 2288
SICI:
8750-7587(200106)90:6<2279:ROTIRM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR ENDOTHELIAL-CELLS; PLATELET-ACTIVATING-FACTOR; HYDROGEN-PEROXIDE; SYNTHETASE INHIBITOR; RECEPTOR ANTAGONIST; A(2) RECEPTOR; ANIMAL-MODEL; NEWBORN PIG; RAT-BRAIN; IN-VITRO;
Keywords:
endothelium; retina; necrosis; apoptosis; peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Chemtob, S Hop St Justine, Res Ctr, Dept Pediat, 3175 Cote Ste, Montreal, PQ H3T 1C5,Canada Hop St Justine 3175 Cote Ste Montreal PQ Canada H3T 1C5 ,Canada
Citazione:
M.H. Beauchamp et al., "Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy", J APP PHYSL, 90(6), 2001, pp. 2279-2288

Abstract

Microvascular degeneration is an important event in oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity. Because oxidant stress abundantly generates thromboxane A(2) (TxA(2)), we tested whether TxA(2) plays a role in retinal vasoobliteration of OIR and contributes to such vascular degeneration by direct endothelial cytotoxicity. Hyperoxia-induced retinal vasoobliteration in rat pups (80% O-2 exposure from postnatal days 5-14)was associated with increased TxB(2) generation and was significantly prevented by TxA(2) synthase inhibitor CGS-12970 (10 mg . kg(-1). day(-1))or TxA(2)-receptor antagonist CGS-22652 (10 mg . kg(-1). day(-1)). TxA(2) mimetics U-46619 (EC50 50 nM) and I-BOP (EC50 5 nM) caused a time- and concentration-dependent cell death of neuroretinovascular endothelial cells from ratsas well as newborn pigs but not of smooth muscle and astroglial cells; other prostanoids did not cause cell death. The peroxidation product 8-iso-PGF(2), which is generated in OIR, stimulated TxA(2) formation by endothelial cells and triggered cell death; these effects were markedly diminished by CGS-12970. TxA(2)-dependent neuroretinovascular endothelial cell death was mostly by necrosis and to a lesser extent by apoptosis. The data identify animportant role for TxA(2) in vasoobliteration of OIR and unveil a so far unknown function for TxA(2) in directly triggering neuroretinal microvascular endothelial cell death. These effects of TxA(2) might participate in other ischemic neurovascular injuries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:13:46