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Titolo:
Alterations in a redox oxygen sensing mechanism in chronic hypoxia
Autore:
Reeve, HL; Michelakis, E; Nelson, DP; Weir, EK; Archer, SL;
Indirizzi:
Vet Affairs Med Ctr, Dept Med, Minneapolis, MN 55417 USA Vet Affairs Med Ctr Minneapolis MN USA 55417 d, Minneapolis, MN 55417 USA Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 pt Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Physiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 hysiol, Minneapolis, MN 55455 USA Univ Alberta, Dept Med, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G 2B7 Med, Edmonton, AB T6G 2B7, Canada Univ Alberta, Dept Physiol, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G 2B7 iol, Edmonton, AB T6G 2B7, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2249 - 2256
SICI:
8750-7587(200106)90:6<2249:AIAROS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; PULMONARY-ARTERY MYOCYTES; GATED K+ CHANNELS; REDUCED GLUTATHIONE; VASCULAR TISSUE; NITRIC-OXIDE; RAT LUNGS; VASOCONSTRICTION; SUPEROXIDE; TONE;
Keywords:
K+ channels; oxygen sensor; glutathione;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Weir, EK Vet Affairs Med Ctr, Dept Med, Cardiol 111C, Minneapolis, MN 55417 USA Vet Affairs Med Ctr Cardiol 111C Minneapolis MN USA 55417 417 USA
Citazione:
H.L. Reeve et al., "Alterations in a redox oxygen sensing mechanism in chronic hypoxia", J APP PHYSL, 90(6), 2001, pp. 2249-2256

Abstract

The mechanism of acute hypoxic pulmonary vasoconstriction (HPV) may involve the inhibition of several voltage-gated K+ channels in pulmonary artery smooth muscle cells. Changes in PO2 can either be sensed directly by the channel(s) or be transmitted to the channel via a redox-based effector mechanism. In control lungs, hypoxia and rotenone acutely decrease production of activated oxygen species, inhibit K+ channels, and cause constriction. Two-day and 3-wk chronic hypoxia (CH) resulted in a decrease in basal activated oxygen species levels, an increase in reduced glutathione, and loss of HPV and rotenone-induced constriction. In contrast, 4-aminopyridine- and KCl-mediated constrictions were preserved. After 3-wk CH, pulmonary arterial smooth muscle cell membrane potential was depolarized, K+ channel density was reduced, and acute hypoxic inhibition of whole cell K+ current was lost. In addition, Kv1.5 and Kv2.1 channel protein was decreased. These data suggestthat chronic reduction of the cytosol occurs before changes in K+ channel expression. HPV may be attenuated in CH because of an impaired redox sensor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:41:01