Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of testosterone and exercise on muscle leanness in eugonadal men with AIDS wasting
Autore:
Fairfield, WP; Treat, M; Rosenthal, DI; Frontera, W; Stanley, T; Corcoran, C; Costello, M; Parlman, K; Schoenfeld, D; Klibanski, A; Grinspoon, S;
Indirizzi:
Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ine Unit, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Gen Clin Res Ctr, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Res Ctr, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 vard Univ, Sch Med, Boston, MA 02114 USA Spaulding Rehabil Hosp, Dept Phys Med & Rehabil, Boston, MA 02114 USA Spaulding Rehabil Hosp Boston MA USA 02114 Rehabil, Boston, MA 02114 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2166 - 2171
SICI:
8750-7587(200106)90:6<2166:EOTAEO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; SKELETAL-MUSCLE; COMPUTED-TOMOGRAPHY; INSULIN SENSITIVITY; BODY-COMPOSITION; DETERMINANTS; TRIALS; WOMEN; MASS;
Keywords:
resistance exercise training; muscle attenuation; acquired immunodeficiency syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Grinspoon, S Massachusetts Gen Hosp, Neuroendocrine Unit, Bulfinch 457B, Boston, MA 02114 USA Massachusetts Gen Hosp Bulfinch 457B Boston MA USA 02114 USA
Citazione:
W.P. Fairfield et al., "Effects of testosterone and exercise on muscle leanness in eugonadal men with AIDS wasting", J APP PHYSL, 90(6), 2001, pp. 2166-2171

Abstract

Loss of lean body and muscle mass characterizes the acquired immunodeficiency syndrome (AIDS) wasting syndrome (AWS). Testosterone and exercise increase muscle mass in men with AWS, with unclear effects on muscle composition. We examined muscle composition in 54 eugonadal men with AWS who were randomized to 1) testosterone (200 mg im weekly) or placebo and simultaneously to 2) resistance training or no training in a 2 x 2 factorial design. At baseline and after 12 wk, we performed assessments of whole body composition by dual-energy X-ray absorptiometry and single-slice computed tomography for midthigh cross-sectional area and muscle composition. Leaner muscle has greater attenuation. Baseline muscle attenuation correlated inversely with whole body fat mass (r = -0.52, P = 0.0001). This relationship persisted in a model including age, body mass index, testosterone level, viral load, lean body mass, and thigh muscle cross-sectional area (P = 0.02). Testosterone(P = 0.03) and training (P = 0.03) increased muscle attenuation. These data demonstrate that thigh muscle attenuation by computed tomography varies inversely with whole body fat and increases with testosterone and training. Anabolic therapy in these patients increases muscle leanness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:14:02