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Titolo:
Attenuation of skeletal muscle and strength in the elderly: The Health ABCStudy
Autore:
Goodpaster, BH; Carlson, CL; Visser, M; Kelley, DE; Scherzinger, A; Harris, TB; Stamm, E; Newman, AB;
Indirizzi:
Univ Pittsburgh, Dept Med, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ept Med, Pittsburgh, PA 15261 USA NIA, Bethesda, MD 20892 USA NIA Bethesda MD USA 20892NIA, Bethesda, MD 20892 USA Univ Colorado, Hlth Sci Ctr, Dept Radiol, Denver, CO 80261 USA Univ Colorado Denver CO USA 80261 Ctr, Dept Radiol, Denver, CO 80261 USA Vrije Univ Amsterdam, Inst Res Extramural Med, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands Med, Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2157 - 2165
SICI:
8750-7587(200106)90:6<2157:AOSMAS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCUTANEOUS ABDOMINAL FAT; CROSS-SECTIONAL AREA; COMPUTED-TOMOGRAPHY; INSULIN SENSITIVITY; DIABETES-MELLITUS; WOMEN; AGE; OBESITY; THIGH; MASS;
Keywords:
aging; computed tomography; adipose tissue; muscle strength;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Goodpaster, BH Univ Pittsburgh, Dept Med, E 1140 Biomed Sci Tower, Pittsburgh, PA 15261 USA Univ Pittsburgh E 1140 Biomed Sci Tower Pittsburgh PA USA15261
Citazione:
B.H. Goodpaster et al., "Attenuation of skeletal muscle and strength in the elderly: The Health ABCStudy", J APP PHYSL, 90(6), 2001, pp. 2157-2165

Abstract

Although loss of muscle mass is considered a cause of diminished muscle strength with aging, little is known regarding whether composition of aging muscle affects strength. The skeletal muscle attenuation coefficient, as determined by computed tomography, is a noninvasive measure of muscle density,and lower values reflect increased muscle lipid content. This investigation examined the hypothesis that lower values for muscle attenuation are associated with lower voluntary isokinetic knee extensor strength at 60 degrees/s in 2,627 men and women aged 70-79 yr participating in baseline studies of the Health ABC Study, a longitudinal study of health, aging, and body composition. Strength was higher in men than in women (132.3 +/- 34.5 vs. 81.4 +/- 22.0 N.m, P < 0.01). Men had greater muscle attenuation values (37.3 <plus/minus> 6.5 vs. 34.7 +/- 7.0 Hounsfield units) and muscle cross-sectional area (CSA) at the midthigh than women (132.7 +/- 22.4 vs. 93.3 +/- 17.5cm(2), P < 0.01 for both). The strength per muscle CSA (specific force) was also higher in men (1.00 <plus/minus> 0.21 vs. 0.88 +/- 0.21 N.m.cm(-2)). The attenuation coefficient was significantly lower for hamstrings than for quadriceps (28.7 +/- 8.7 vs. 41.1 +/- 6.9 Hounsfield units, P < 0.01). Midthigh muscle attenuation values were lowest (P < 0.01) in the eldest men and women and were negatively associated with total body fat (r = -0.53, P <0.01). Higher muscle attenuation values were also associated with greater specific force production (r = 0.26, P < 0.01). Multivariate regression analysis revealed that the attenuation coefficient of muscle was independentlyassociated with muscle strength after adjustment for muscle CSA and midthigh adipose tissue in men and women. These results demonstrate that the attenuation values of muscle on computed tomography in older persons can account for differences in muscle strength not attributed to muscle quantity.

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Documento generato il 29/03/20 alle ore 09:28:14