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Titolo:
Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats
Autore:
Palmer, BM; Lynch, JM; Snyder, SM; Moore, RL;
Indirizzi:
Univ Colorado, Dept Kinesiol & Appl Physiol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 & Appl Physiol, Boulder, CO 80309 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2063 - 2069
SICI:
8750-7587(200106)90:6<2063:RHPRTM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR MYOCYTES; EXERCISE; MYOCARDIUM; EXCHANGE; HEART; NA+;
Keywords:
sodium ion/calcium ion exchange; sodium ion/calcium ion exchanger; fura 2; sarcoplasmic reticulum; treadmill;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, RL Univ Colorado, Dept Kinesiol & Appl Physiol, Campus Box 354, Boulder, CO 80309 USA Univ Colorado Campus Box 354 Boulder CO USA 80309 , CO 80309 USA
Citazione:
B.M. Palmer et al., "Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats", J APP PHYSL, 90(6), 2001, pp. 2063-2069

Abstract

The combined effects of endurance run training and renal hypertension on cytosolic Ca2+ concentration ([Ca2(+)](c)) dynamics and Na+-dependent Ca2+ regulation in rat left ventricular cardiomyocytes were examined. Male Fischer 344 rats underwent stenosis of the left renal artery [hypertensive (Ht), n = 18] or a sham operation [normotensive (Nt), n = 20]. One-half of the rats from each group were treadmill trained for >16 wk. Cardiomyocyte fura 2 fluorescence ratio transients were recorded for 7 min during electrical pacing at 0.5 Hz, 2 mM extracellular Ca2+ concentration, and 29 degreesC. The rate of [Ca2+](c) decline was not changed by run training in the Nt group but was reduced in the Ht group. At 7 min, cardiomyocytes were exposed to 10mM caffeine in the absence of Na+ and Ca2+, which triggered sarcoplasmic reticular Ca2+ release and suppressed Ca2+ efflux via Na+/Ca2+ exchanger. External Na+ was then added, and Na+-dependent Ca2+ efflux rate was recorded. Treadmill training significantly enhanced Na+-dependent Ca2+ efflux rate under these conditions in the Nt group but not in the Ht group. These data provide evidence that renal hypertension prevents the normal run training-induced modifications in diastolic [Ca2+](c) regulation mechanisms, includingNa+/Ca2+ exchanger.

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Documento generato il 23/01/20 alle ore 03:46:39