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Titolo:
Living and training in moderate hypoxia does not improve Vo(2max) more than living and training in normoxia
Autore:
Henderson, KK; Clancy, RL; Gonzalez, NC;
Indirizzi:
Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 t Physiol, Kansas City, KS 66160 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 90, anno: 2001,
pagine: 2057 - 2062
SICI:
8750-7587(200106)90:6<2057:LATIMH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAXIMAL OXYGEN-UPTAKE; O-2 TRANSPORT; ALTITUDE ACCLIMATIZATION; SIMULATED ALTITUDE; EXERCISE; MUSCLE; RATS; PERFORMANCE; VASORELAXATION; LIMITATION;
Keywords:
maximal O-2 uptake; maximal exercise capacity; exercise training; hypoxic exercise; systemic O-2 transport; tissue O-2 delivery; tissue O-2 extraction; hypoxic pulmonary vasoconstriction; hypoxic pulmonary hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez, NC Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KS USA 66160 60 USA
Citazione:
K.K. Henderson et al., "Living and training in moderate hypoxia does not improve Vo(2max) more than living and training in normoxia", J APP PHYSL, 90(6), 2001, pp. 2057-2062

Abstract

The objective of these experiments was to determine whether living and training in moderate hypoxia (MHx) confers an advantage on maximal normoxic exercise capacity compared with living and training in normoxia. Rats were acclimatized to and trained in MHx [inspired PO2 (PIO2) = 110 Torr] for 10 wk(HTH). Rats living in normoxia trained under normoxic conditions (NTN) at the same absolute work rate: 30 m/min on a 10 degrees incline, 1 h/day, 5 days/wk. At the end of training, rats exercised maximally in normoxia. Training increased maximal O-2 consumption ((V)over dot O-2 max) in NTN and HTH above normoxic (NS) and hypoxic (HS) sedentary controls. However, (V)over dot O-2 max and O-2 transport variables were not significantly different between NTN and HTH: (V)over dot O-2 max 86.6 +/- 1.5 vs. 86.8 +/- 1.1 ml.min(-1).kg(-1); maximal cardiac output 456 +/- 7 vs. 443 +/- 12 ml.min(-1).kg(-1); tissue blood O-2 delivery (cardiac output x arterial O-2 content) 95 +/- 2 vs. 96 +/- 2 ml.min(-1).kg(-1); and O-2 extraction ratio (arteriovenousO-2 content difference/arterial O-2 content) 0.91 +/- 0.01 vs. 0.90 +/- 0.01. Mean pulmonary arterial pressure (Ppa, mmHg) was significantly higher in HS vs. NS (P < 0.05) at rest (24.5 <plus/minus> 0.8 vs. 18.1 +/- 0.8) andduring maximal exercise (32.0 +/- 0.9 vs. 23.8 +/- 0.6). Training in MHx significantly attenuated the degree of pulmonary hypertension, with Ppa being significantly lower at rest (19.3 +/- 0.8) and during maximal exercise (29.2 +/- 0.5) in HTH vs. HS. These data indicate that, despite maintaining equal absolute training intensity levels, acclimatization to and training inMHx does not confer significant advantages over normoxic training. On the other hand, the pulmonary hypertension associated with acclimatization to hypoxia is reduced with hypoxic exercise training.

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Documento generato il 20/09/20 alle ore 00:26:41