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Titolo:
Is antidepressant-benzodiazepine combination therapy clinically more useful? A meta-analytic study
Autore:
Furukawa, TA; Streiner, DL; Young, LT;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Psychiat, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Univ Toronto, Baycrest Ctr Geriatr Res, Toronto, ON, Canada Univ Toronto Toronto ON Canada rest Ctr Geriatr Res, Toronto, ON, Canada McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada & Behav Neurosci, Hamilton, ON, Canada
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 2, volume: 65, anno: 2001,
pagine: 173 - 177
SICI:
0165-0327(200107)65:2<173:IACTCM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; DEPRESSION; PLACEBO; AMITRIPTYLINE; LIMBITROL;
Keywords:
major depression; drug therapy; antidepressants; benzodiazepines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, TA Nagoya City Univ, Sch Med, Dept Psychiat, Mizuho Ku, Mizuho Cho, Nagoya, Aichi 4678601, Japan Nagoya City Univ Mizuho Cho Nagoya Aichi Japan 4678601 Japan
Citazione:
T.A. Furukawa et al., "Is antidepressant-benzodiazepine combination therapy clinically more useful? A meta-analytic study", J AFFECT D, 65(2), 2001, pp. 173-177

Abstract

Background: Anxiety frequently coexists with depression, and benzodiazepines are often prescribed together with antidepressants. However, benzodiazepines themselves have little or no antidepressive effects and we lack firm evidence for or against this combination therapy. We therefore conducted a meta-analysis of relevant randomized controlled trials to date. Methods: Allrandomized controlled trials that compared antidepressant-benzodiazepine treatment with antidepressant alone for adult patients with major depressionwere sought by electronic searches of Medline and several other databases (January 1972 to December 1998), combined with hand searching, reference searching and SciSearch. Two reviewers independently assessed the eligibilityand quality of the studies. Relative risks were estimated with random effects model. Results: Aggregating nine studies with a total of 679 patients, the combination therapy group was 37% (95%CI: 19-51%) less likely to drop out than the antidepressant alone group. The intention-to-treat analysis showed that the former were 63% (18-127%) to 38% (15-66%) more likely to show response (defined as 50% or greater reduction in the depression scale from baseline) up to 4 weeks. Limitations: None of the included RCTs followed the patients beyond 8 weeks. Conclusions: The potential benefits of adding a benzodiazepine to an antidepressant must be balanced judiciously against possible harm, including development of dependence and accident proneness, onthe one hand, and against continued suffering following no response and drop-out, on the other. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 19:17:38