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Titolo:
Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder - a negative study
Autore:
Fujimaki, K; Morinobu, S; Takahashi, J; Yamawaki, S; Kato, N; Kanno, M; Okuyama, N; Kawakatsu, S; Otani, K; Kusumi, I; Koyama, T;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Hiroshima, Japan Hiroshima Univ Hiroshima Japan pt Psychiat & Neurosci, Hiroshima, Japan Shiga Univ Med Sci, Dept Psychiat, Otsu, Shiga 52021, Japan Shiga Univ MedSci Otsu Shiga Japan 52021 chiat, Otsu, Shiga 52021, Japan Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan Univ Tokyo Tokyo Japan , Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan Yamagata Univ, Sch Med, Dept Neuropsychiat, Yamagata, Japan Yamagata UnivYamagata Japan h Med, Dept Neuropsychiat, Yamagata, Japan Hokkaido Univ, Sch Med, Dept Psychiat, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 at, Sapporo, Hokkaido 060, Japan
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 2, volume: 65, anno: 2001,
pagine: 139 - 143
SICI:
0165-0327(200107)65:2<139:NSAOTB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPRESSED-PATIENTS; CALCIUM RESPONSE; EXPRESSION; SEROTONIN; PLATELETS; AGONIST; CALCINEURIN; BRAIN;
Keywords:
bipolar disorder; inositol 1,4,5-trisphosphate receptor; calcium; calcineurin; FKBP-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Morinobu, S Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Hiroshima, Japan Hiroshima Univ Hiroshima Japan & Neurosci, Hiroshima, Japan
Citazione:
K. Fujimaki et al., "Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder - a negative study", J AFFECT D, 65(2), 2001, pp. 139-143

Abstract

Pharmacological studies of bipolar disorder suggest that dysfunction of calcium mobilization via phosphatidylinositol-mediated transduction may be involved in its pathogenesis. The present study tests the hypothesis that dysfunction of calcium mobilization in bipolar disorder is due to the mutationof the nucleotide sequence in the FKBP12 binding site on the inositol 1,4,5-trisphosphate type-1 receptor (IP(3)R1). Nucleotide sequence analysis of the FKBP12 binding site on IP(3)R1 was performed using reverse transcription-polymerase chain reaction and DNA sequencing. The nucleotide sequence in this region was preserved in all subjects. This finding suggests that IP(3)R1 dysfunction through the FKBP12 binding site is not involved in the pathogenesis of bipolar disorder. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:51:39