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Titolo:
Using isoproterenol stress echocardiography to predict the response to carvedilol in patients with dilated cardiomyopathy
Autore:
Nishi, I; Iida, K; Kawano, S; Masumi, T; Yamaguchi, I;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 6, volume: 65, anno: 2001,
pagine: 514 - 518
SICI:
0047-1828(200106)65:6<514:UISETP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC-BLOCKADE; CONGESTIVE-HEART-FAILURE; HYPERTROPHIC CARDIOMYOPATHY; CARDIAC-FUNCTION; DOUBLE-BLIND; IMPROVEMENT; THERAPY; TERM; CONTRACTILE; METOPROLOL;
Keywords:
carvedilol; dilated cardiomyopathy; echocardiography; isoproterenol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kawano, S Univ Tsukuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennoudai Tsukuba Ibaraki Japan 3058575 Japan
Citazione:
I. Nishi et al., "Using isoproterenol stress echocardiography to predict the response to carvedilol in patients with dilated cardiomyopathy", JPN CIRC J, 65(6), 2001, pp. 514-518

Abstract

Trials have demonstrated that carvedilol can produce hemodynamic, symptomatic, and prognostic improvements in dilated cardiomyopathy (DCM), but some DCM patients have deteriorated after carvedilol, developing congestive heart failure. The present study investigated the use of isoproterenol (ISP) stress echocardiography to select those patients with DCM who would respond to carvedilol. ISP was infused intravenously in 22 patients with DCM and they were classified into 2 groups based on the left ventricular systolic response: good response to TSP [change in fractional shortening (FS) with ISP >0.05, n = 13] and poor response to ISP (change less than or equal to0.05, n= 9). In the good response group, FS significantly increased from 0.12 +/-0.04 to 0.17 +/- 0.08 (mean +/- SD, p < 0.05) with carvedilol, and ? patients improved symptomatically (New York Heart Association class). However, in the poor response group, no significant difference was observed between FS at baseline and that at the end of follow-up. Moreover, only I patient inthe poor response group improved symptomatically. ISP stress echocardiography can assist in selecting patients with DCM who will respond positively to carvedilol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:53:18