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Titolo:
Lipid peroxidation may predict restenosis after coronary balloon angioplasty
Autore:
Imai, K; Matsubara, T; Kanashiro, M; Ichimiya, S; Hotta, N;
Indirizzi:
Nagoya Univ, Sch Med, Dept Internal Med 3, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Yokkaichi Municipal Hosp, Dept Cardiol, Yokkaichi, Japan Yokkaichi Municipal Hosp Yokkaichi Japan Dept Cardiol, Yokkaichi, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 6, volume: 65, anno: 2001,
pagine: 495 - 499
SICI:
0047-1828(200106)65:6<495:LPMPRA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; VITAMIN-E; ARTERY DISEASE; ATHEROSCLEROSIS; PROBUCOL; OXIDATION; PLASMA; PREVENTION; AUTOANTIBODIES; REPERFUSION;
Keywords:
coronary balloon angioplasty; lipid peroxidation; restenosis; thiobarbituric acid reactive substances;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Matsubara, T Nagoya Univ, Sch Med, Dept Internal Med 3, Showa Ku, 65 Tsurumai-cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsurumai-cho Nagoya Aichi Japan 4668550 Japan
Citazione:
K. Imai et al., "Lipid peroxidation may predict restenosis after coronary balloon angioplasty", JPN CIRC J, 65(6), 2001, pp. 495-499

Abstract

The present study assessed whether lipid peroxidation in plasma might predict restenosis after coronary balloon angioplasty. A total of 87 patients, who had undergone successful coronary balloon angioplasty using standard techniques, were enrolled. Fasting blood samples before the intervention weremeasured for plasma levels of thiobarbituric acid reactive substances (TBARS, an indicator of lipid peroxidation). Angiography was carried out beforeand 15 min after angioplasty, and at follow-up (4 months after angioplasty), and evaluated using a quantitative approach. There were 23 patients withrestenosis (group R) and 64 patients without restenosis (group N) after coronary balloon angioplasty. The plasma TEARS level (mean +/- SEM) of 4.3 +/- 0.1 mu mol/L in group R was significantly higher than that of 3.2 +/- 0.1mu mol/L in group N (p < 0.01). There were no significant differences in other parameters, including plasma lipid levels, between the 2 groups. The plasma level of TEARS positively correlated with lumen loss of the coronary artery at the time of follow-up angiography (r = 0.57, p < 0.01). Our results suggest that oxidative stress contributes to restenosis and indicate that an elevated plasma level of TEARS may be a reliable predictor of restenosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 22:46:32