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Titolo:
Serum thioredoxin (TRX) levels in patients with heart failure
Autore:
Kishimoto, C; Shioji, K; Nakamura, H; Nakayama, Y; Yodoi, J; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Inst Virus Res, Dept Biol Responses, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 us Res, Dept Biol Responses, Kyoto 606, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 6, volume: 65, anno: 2001,
pagine: 491 - 494
SICI:
0047-1828(200106)65:6<491:ST(LIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA-DERIVED FACTOR; FREE-RADICAL SYSTEM; REPERFUSION; EXPRESSION; INJURY; PROTECTION; ACTIVATION; DAMAGE;
Keywords:
heart failure; oxidative stress; thioredoxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kishimoto, C Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawaracho, Kyoto 6068507, Japan Kyoto Univ 54 Kawaracho Kyoto Japan 6068507o 6068507, Japan
Citazione:
C. Kishimoto et al., "Serum thioredoxin (TRX) levels in patients with heart failure", JPN CIRC J, 65(6), 2001, pp. 491-494

Abstract

An increase in oxidative stress is thought to be involved in the progression of heart disease, but the serum level of thioredoxin (TRX), which regulates the cellular redox state, has not been investigated in patients with heart diseases. The present study determined serum TRX levels with a sandwichenzyme-linked immunosorbent assay in a total of 39 patients with dilated cardiomyopathy (DCM) (n = 5), acute coronary syndrome (ACS) (n = 7) or stable angina (n = 18), including effort angina (n = 7) and vasospastic angina (n = 11), and in control subjects (n = 7). The serum TRX level in patients with New York Heart Association (NYHA) functional classes III and IV (n = 8,33.3 +/- 8.6 ng/ml) was significantly higher than in the control subjects (n = 7, 14.0 +/- 4.6 ng/ml). In addition, the serum TRX levels correlated positively with the severity of NYHA class, and negatively with the left ventricular ejection fraction. The serum TRX levels were elevated in patients with ACS and DCM compared with the controls. These results indicate a possible association between TRX concentration and the severity of heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 10:52:44