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Titolo:
NADPH-diaphorase colocalization with somatostatin receptor subtypes sst2A and sst2B in the retina
Autore:
Vasilaki, A; Gardette, R; Epelbaum, J; Thermos, K;
Indirizzi:
Univ Crete, Fac Med, Dept Basic Sci, Pharmacol Lab, Heraklion 71110, Crete, Greece Univ Crete Heraklion Crete Greece 71110 b, Heraklion 71110, Crete, Greece Inst Natl Sante & Rech Med U159, Paris, France Inst Natl Sante & Rech Med U159 Paris France ch Med U159, Paris, France
Titolo Testata:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
fascicolo: 7, volume: 42, anno: 2001,
pagine: 1600 - 1609
SICI:
0146-0404(200106)42:7<1600:NCWSRS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; GTP-BINDING-PROTEINS; RABBIT RETINA; RAT RETINA; FUNCTIONAL-CHARACTERIZATION; SPLICE VARIANT; LOCALIZATION; EXPRESSION; CELLS; CYCLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Thermos, K Univ Crete, Fac Med, Dept Basic Sci, Pharmacol Lab, Heraklion 71110, Crete, Greece Univ Crete Heraklion Crete Greece 71110 n 71110, Crete, Greece
Citazione:
A. Vasilaki et al., "NADPH-diaphorase colocalization with somatostatin receptor subtypes sst2A and sst2B in the retina", INV OPHTH V, 42(7), 2001, pp. 1600-1609

Abstract

PURPOSE. TO investigate the differential localization of somatotropin release-inhibitory factor (SRIF) receptor subtypes (sst2A and sst2B) and their possible colocalization with reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase in the rat and rabbit retina. METHODS. Polyclonal antibodies raised against sst2A and sst2B receptors were applied to 10- to 14-mum cryostat sections of rat and rabbit retinas fixed in paraformaldehyde. NADPH-diaphorase reactivity was assessed histochemically. Double labeling was performed for sst2A or sst2B receptors with NADPH-diaphorase, and with markers for the cell types present in the retina (protein kinase C [PKC], tyrosine hydroxylase; [TH], calbindin, and recoverin). RESULTS. SSt2A immunoreactivity was detected in rod bipolar cells and colocalized with NADPH-diaphorase in the rabbit, but not the rat, retina, sst2Bwas present only in photoreceptor cells of the rat and colocalized with NADPH-diaphorase. CONCLUSIONS. These results suggest that SRIF, acting through sst2A receptors in bipolar cells and sst2B receptors in photoreceptor cells, may affect nitric oxide function in the rabbit and rat retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:52:57