Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The pharmacological rationale for treating vascular dementia with galantamine (Reminyl(Tau Mu))
Autore:
Maelicke, A;
Indirizzi:
Univ Mainz, Sch Med, Inst Physiol Chem & Pathobiochem, Mainz, Germany UnivMainz Mainz Germany st Physiol Chem & Pathobiochem, Mainz, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
, , anno: 2001, supplemento:, 120
pagine: 24 - 28
SICI:
1368-5031(200105):<24:TPRFTV>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; NICOTINIC ACETYLCHOLINE-RECEPTORS; PLACEBO-CONTROLLED TRIAL; ALZHEIMERS-DISEASE; CHOLINERGIC HYPOTHESIS; TREATMENT STRATEGY; ALLOSTERIC MODULATION; CEREBROSPINAL-FLUID; PARKINSONS-DISEASE; MEMORY;
Keywords:
Alzheimer's disease; cholinergic deficit; galantamine; nicotinic receptors; vascular dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Maelicke, A Univ Mainz, Sch Med, Inst Physiol Chem & Pathobiochem, Mainz, Germany Univ Mainz Mainz Germany hem & Pathobiochem, Mainz, Germany
Citazione:
A. Maelicke, "The pharmacological rationale for treating vascular dementia with galantamine (Reminyl(Tau Mu))", INT J CL PR, 2001, pp. 24-28

Abstract

There is considerable evidence indicating that, as in Alzheimer's disease,the central cholinergic system is impaired in vascular dementia (VaD). Using lessons learned from Alzheimer's disease research, if has been proposed that enhancement of the cholinergic system is a rational approach to treating the symptoms of VaD. Galantamine's dual mode of action may provide a greater chance of success in treating patients with Alzheimer's disease through enhanced efficacy on the cognitive, functional and behavioural aspects of dementia. Trials are currently underway to see if this broad spectrum of efficacy extends to patients with Alzheimer's disease with cerebrovascular disease ('mixed' dementia) or VaD, as well as other conditions, and the results are eagerly awaited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:53:38