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Titolo:
Hypothyroidism provides resistance to reperfusion injury following myocardium ischemia
Autore:
Bobadilla, I; Franco, M; Cruz, D; Zamora, J; Robles, SG; Chavez, E;
Indirizzi:
Inst Nacl Cardiol Ignacio Chavez, Dept Bioquim, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico 14080 , DF, Mexico Inst Nacl Cardiol Ignacio Chavez, Dept Nefrol, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico 14080 , DF, Mexico Inst Nacl Cardiol Ignacio Chavez, Dept Patol, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico 14080 , DF, Mexico Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico 14080 , DF, Mexico
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 5, volume: 33, anno: 2001,
pagine: 499 - 506
SICI:
1357-2725(200105)33:5<499:HPRTRI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL PERMEABILITY TRANSITION; INDUCED ARRHYTHMIAS; CA-2+-DEPENDENT PORE; HEART-MITOCHONDRIA; LIVER-MITOCHONDRIA; OXIDATIVE STRESS; CYCLOSPORINE-A; CALCIUM; RAT; MEMBRANE;
Keywords:
hypothyroidism; ischemia/reperfusion; rat heart; myocardium reperfusion; reperfusion injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Chavez, E Inst Nacl Cardiol Ignacio Chavez, Dept Bioquim, Juan Badiano 1, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Juan Badiano1 Mexico City DF Mexico 14080
Citazione:
I. Bobadilla et al., "Hypothyroidism provides resistance to reperfusion injury following myocardium ischemia", INT J BIO C, 33(5), 2001, pp. 499-506

Abstract

A growing body of evidence has demonstrated that reperfusion injury may bemediated, in part, by mitochondrial Ca2+ overload that promotes non-selective permeability of the inner membrane. In this regard it is known that mitochondria from hypothyroid rats are resistant to membrane damage as inducedby Ca2+. The purpose of this study was to evaluate the sensitivity of hearts from hypothyroid rats, to the damage by reperfusion, after an ischemic period of 5 min. The results were compared with those from control and hyperthyroid rats. Hypothyroidism was established by surgical removal of the thyroid gland; in turn hyperthyroidism was induced after a daily injection of 2 mg/kg of 3,5,3'-triiodothyronine for 4 days. ECG tracings from hypothyroid rats showed a total absence of post-reperfusion arrhythmias conversely towhat was observed in control and hyperthyroid rats. The release of creatine kinase and aspartate amino transferase to the plasma in hypothyroid rats was found to be lower than that found in hyperthyroid and euthyroid rats. The histological studies showed that myocardial fibers from hypothyroid ratswere in good condition and retained their striae and a remarkable near absence of edema was clearly observed. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:26:14