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Titolo:
The Ca2+/calmodulin system in neuronal hyperexcitability
Autore:
Sola, C; Barron, S; Tusell, JM; Serratosa, J;
Indirizzi:
IDIBAPS, CSIC, Inst Invest Biomed Barcelona, Dept Pharmacol & Toxicol, Barcelona 08036, Spain IDIBAPS Barcelona Spain 08036 harmacol & Toxicol, Barcelona 08036, Spain IDIBAPS, CSIC, Inst Invest Biomed Barcelona, Dept Neurochem, Barcelona 08036, Spain IDIBAPS Barcelona Spain 08036 na, Dept Neurochem, Barcelona 08036, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 5, volume: 33, anno: 2001,
pagine: 439 - 455
SICI:
1357-2725(200105)33:5<439:TCSINH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALMODULIN MESSENGER-RNA; DEPENDENT PROTEIN-KINASE; CENTRAL-NERVOUS-SYSTEM; TRANSIENT FOREBRAIN ISCHEMIA; CALCIUM-CHANNEL BLOCKERS; RAT-BRAIN; GENE-EXPRESSION; MOUSE-BRAIN; ANTICONVULSANT ACTIVITY; STRUCTURAL ORGANIZATION;
Keywords:
calmodulin; calmodulin-binding protein; convulsion; central nervous system; c-fos expression;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Sola, C IDIBAPS, CSIC, Inst Invest Biomed Barcelona, Dept Pharmacol & Toxicol, C Rossello 161,6th Floor, Barcelona 08036, Spain IDIBAPS C Rossello 161,6th Floor Barcelona Spain 08036 036, Spain
Citazione:
C. Sola et al., "The Ca2+/calmodulin system in neuronal hyperexcitability", INT J BIO C, 33(5), 2001, pp. 439-455

Abstract

Calmodulin (CaM) is a major Ca2+-binding protein in the brain, where it plays an important role in the neuronal response to changes in the intracellular Ca2+ concentration. Calmodulin modulates numerous Ca2+-dependent enzymes and participates in relevant cellular functions. Among the different CaM-binding proteins, the Ca2+/CaM dependent protein kinase II and the phosphatase calcineurin are especially important in the brain because of their abundance and their participation in numerous neuronal functions. Therefore, the role of the Ca2+/CaM signalling system in different neurotoxicological orneuropathological conditions associated to alterations in the intracellular Ca2+ concentration is a subject of interest. We here report different evidences showing the involvement of CaM and the CaM-binding proteins above mentioned in situations of neuronal hyperexcitability induced by convulsant agents. Signal transduction pathways mediated by specific CaM binding proteins warrant future study as potential targets in the development of new drugs to inhibit convulsant responses or to prevent or attenuate the alterations in neuronal function associated to the deleterious increases in the intracellular Ca2+ levels described in different pathological situations. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:58:00