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Titolo:
Glomerular injury induced in mice by intraperitoneal injection of Shiga-like toxins
Autore:
Koshi, R; Pulimood, AB; Date, A; Kang, G; Acheson, D; Mathan, MM;
Indirizzi:
Christian Med Coll & Hosp, Dept Anat, Vellore 632002, Tamil Nadu, India Christian Med Coll & Hosp Vellore Tamil Nadu India 632002 mil Nadu, India Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore 632002, Tamil Nadu, India Christian Med Coll & Hosp Vellore Tamil Nadu India 632002 mil Nadu, India Sultan Qaboos Univ, Dept Pathol, Muscat, Oman Sultan Qaboos Univ Muscat Oman n Qaboos Univ, Dept Pathol, Muscat, Oman Tufts Univ, Dept Geog Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Univ, Dept Geog Med, Boston, MA 02111 USA
Titolo Testata:
INDIAN JOURNAL OF MEDICAL RESEARCH
, volume: 113, anno: 2001,
pagine: 63 - 69
SICI:
0971-5916(200102)113:<63:GIIIMB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOLYTIC-UREMIC SYNDROME; ESCHERICHIA-COLI O157-H7; MOUSE MODEL; LIPOPOLYSACCHARIDE; HISTOPATHOLOGY; SHIGELLOSIS; INFECTION; CELLS;
Keywords:
capillary endothelium; microvasculature; renal; Stx1; Stx2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Koshi, R Christian Med Coll & Hosp, Dept Anat, Vellore 632002, Tamil Nadu,India Christian Med Coll & Hosp Vellore Tamil Nadu India 632002 India
Citazione:
R. Koshi et al., "Glomerular injury induced in mice by intraperitoneal injection of Shiga-like toxins", I J MED RES, 113, 2001, pp. 63-69

Abstract

Background & objectives : Shiga-like toxins I and II (Stx1 and Stx2) play an important role in the pathogenesis of renal disease by causing renal microvascular injury. A murine model was used to study glomerular lesions produced by Stx1 and Stx2,Methods : Swiss albino mice of the Rockefeller strain were inoculated intraperitoneally with LD50 doses of endotoxin-free Stx1 or Stx2 and observed for signs of disease. Samples of renal cortical tissue from mice were examined with the electron microscope. Results : The mice developed systemic and neurological symptoms including hind limb paralysis and generalised convulsions. Renal arteriolar damage and glomerular endothelial cytoplasmic swelling, vacuolation, lysis and intravascular coagulation were present and resembled the microangiopathy seen inrenal biopsies from patients. Interpretation & conclusions : These experiments establish the role of Stx1 and Stx2 in glomerular vascular injury and provide a model for studying the pathogenesis of Shiga-like toxin related microangiopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:00:51