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Titolo:
The role of complement in inflammation and adaptive immunity
Autore:
Barrington, R; Zhang, M; Fischer, M; Carroll, MC;
Indirizzi:
Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pediat, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 Dept Pediat, Cambridge, MA 02138 USA Univ Vienna, Inst Immunol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Inst Immunol, Vienna, Austria
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 180, anno: 2001,
pagine: 5 - 15
SICI:
0105-2896(200104)180:<5:TROCII>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE SEPTIC PERITONITIS; T-DEPENDENT ANTIGEN; B-CELL RESPONSE; ANTIBODY-RESPONSE; LYMPHOCYTES-B; REPERFUSION INJURY; GERMINAL-CENTERS; GUINEA-PIGS; RECEPTOR; CD19;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Carroll, MC Harvard Univ, Sch Med, Ctr Blood Res, 200 Longwood Ave, Boston, MA 02115 USA Harvard Univ 200 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
R. Barrington et al., "The role of complement in inflammation and adaptive immunity", IMMUNOL REV, 180, 2001, pp. 5-15

Abstract

Major advances in our understanding of the immunobiology of complement were made within the past 5 years primarily due to the development of gene-targeting technology. New strains of mice bearing specific deficiencies in serum complement proteins or their receptors were developed using this approach. Characterization of these mice has provided new and exciting insights into the biology of the complement system. In this review, we discuss recent results on two important aspects of the complement system, i) host protection and inflammation, and ii) regulation of B lymphocytes of adaptive immunity. While these two roles appear distinct, they are linked. We discuss how natural antibody and classical pathway complement work together in host protection against bacterial infection on the one hand bur, on the other, theyco-operate to induce inflammation as observed in reperfusion injury. Significantly, the lymphocytes that produce natural antibody, the B-1 lymphocytes, are regulated in part by the complement system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:32:09