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Titolo:
Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopicorganization
Autore:
Grodd, W; Hulsmann, E; Lotze, M; Wildgruber, D; Erb, M;
Indirizzi:
Univ Tubingen, Dept Neuroradiol, Sect Expt MR CNS, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 MR CNS, D-72076 Tubingen, Germany
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 2, volume: 13, anno: 2001,
pagine: 55 - 73
SICI:
1065-9471(200106)13:2<55:SMOTHC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; FUNCTIONAL MRI; GRANULE CELL; MOTOR CONTROL; ACTIVATION; PROJECTIONS; AREAS; RAT; CAT;
Keywords:
functional magnetic resonance imaging (fMRI); cerebellum; somatotopy; voluntary movement; brain mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Grodd, W Univ Tubingen, Dept Neuroradiol, Sect Expt MR CNS, Hoppe Seyler Str 3, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 3 Tubingen Germany D-72076 ermany
Citazione:
W. Grodd et al., "Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopicorganization", HUM BRAIN M, 13(2), 2001, pp. 55-73

Abstract

Functional magnetic resonance imaging (fMRI) was employed to determine areas of activation in the cerebellar cortex in 46 human subjects during a series of motor tasks. To reduce the variance due to differences in individualanatomy, a specific transformational procedure for the cerebellum was introduced. The activation areas for movements of lips, tongue, hands, and feetwere determined and found to be sharply confined to lobules and sublobulesand their sagittal zones in the rostral and caudal spine-cerebellar cortex. There was a clear symmetry mirroring at the midline. The activation mapped as two distinct homunculoid representations. One, a more extended representation, was located upside down in the superior cerebellum, and a second one, doubled and smaller, in the inferior cerebellum. The two representations were remarkably similar to those proposed by Snider and Eldred [1951] five decades ago. In the upper representation, an intralimb somatotopy for theright elbow, wrist, and fingers was revealed. The maps seem to confirm earlier electrophysiological findings of sagittal zones in animals. They differ, however, from micromapping reports on fractured somatotopic maps in the cerebellar cortex of mammals. We assume that the representations that we observed are not solely the result of spatial integration of hemodynamic events underlying the fMRI method and may reflect integration of afferent peripheral and central information in the cerebellar cortex. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:31:19