Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Does laser injury induce a different neovascularisation pattern from mechanical or ischaemic injuries?
Autore:
Mueller, XM; Tevaearai, HT; Chaubert, P; Genton, CY; von Segesser, LK;
Indirizzi:
CHU Vaudois, Cardiovasc Surg Clin, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland CHU Vaudois, Dept Pathol, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland
Titolo Testata:
HEART
fascicolo: 6, volume: 85, anno: 2001,
pagine: 697 - 701
SICI:
1355-6037(200106)85:6<697:DLIIAD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMYOCARDIAL CHANNELS; HISTOLOGICAL FEATURES; LONG-TERM; REVASCULARIZATION; CO2-LASER; MYOCARDIUM; ISCHEMIA;
Keywords:
laser revascularisation; angiogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mueller, XM CHU Vaudois, Cardiovasc Surg Clin, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 usanne, Switzerland
Citazione:
X.M. Mueller et al., "Does laser injury induce a different neovascularisation pattern from mechanical or ischaemic injuries?", HEART, 85(6), 2001, pp. 697-701

Abstract

Aim - To analyse the arteriolar pattern of laser induced channels and their surroundings compared with mechanical and ischaemic injury. Methods - 24 pigs were randomised to a myocardial infarction group, a transmyocardial laser revascularisation group, a needle group, or a control group. In the laser revascularisation and needle groups, five channels were created either with a 1.75 mm probe holmium-YAG laser or a Tru-cut needle of the same size. Animals were killed 28 days later. Morphometric analysis of vascular density was expressed as the mean (SD) number of arteriolar structures/cm(2). Results - Laser and needle channels were completely invaded by granulationtissue. Their surface areas did not differ significantly: 2.28 (0.7)mm(2) and 2.38 (1.1)mm(2), respectively (p = 0.82). Within both types of channel,arteriolar density was significantly increased in comparison with the myocardial infarction scar: 197 (52)/cm(2) and 190 (64)/cm(2), respectively (p = 0.8) versus 56 (20)/cm(2) (p < 0.001 for both comparisons). The area of 1mm width immediately adjacent to the laser and needle channels showed a density of 25 (16)/cm(2) and 23 (18)/cm(2), respectively, which is similar tothat of normal tissue (28 (10)/cm(2); p = 0.6 and p = 0.4, respectively). The mean arteriolar diameter was similar throughout all the regions analysed. Conclusions - Both laser and needle channels produce a similar increase inarteriolar structures, which is limited to the lesion itself. This suggests that laser injury is not more potent as an angiogenic stimulator than mechanical injury, which in turn is superior to infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:39:43