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Titolo:
The vitamin D receptor genotype predisposes to the development of calcificaortic valve stenosis
Autore:
Ortlepp, JR; Hoffmann, R; Ohme, F; Lauscher, J; Bleckmann, F; Hanrath, P;
Indirizzi:
Univ Hosp Aachen, Med Clin 1, D-52057 Aachen, Germany Univ Hosp Aachen Aachen Germany D-52057 Clin 1, D-52057 Aachen, Germany
Titolo Testata:
HEART
fascicolo: 6, volume: 85, anno: 2001,
pagine: 635 - 638
SICI:
1355-6037(200106)85:6<635:TVDRGP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; GENE POLYMORPHISMS; MYOCARDIAL-INFARCTION; WOMEN; MASS; ASSOCIATION; ALLELES; DISEASE; SPINE; RISK;
Keywords:
vitamin D receptor; calcific aortic stenosis; aortic valve; generic polpmorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ortlepp, JR Univ Hosp Aachen, Med Clin 1, Pauwelsstr 30, D-52057 Aachen, Germany Univ Hosp Aachen Pauwelsstr 30 Aachen Germany D-52057 Germany
Citazione:
J.R. Ortlepp et al., "The vitamin D receptor genotype predisposes to the development of calcificaortic valve stenosis", HEART, 85(6), 2001, pp. 635-638

Abstract

Objective - To test the hypothesis that vitamin D receptor polymorphism isassociated with calcific aortic valve stenosis. Design - The distribution of one polymorphism of the vitamin D receptor (BsmI B/b) was examined in 100 consecutive patients with calcific valvar aortic stenosis and compared with a control group of 100 patients (paired matchfor age, sex, and the presence of coronary artery disease from a total of 630 patients without calcified aortic valves). Polymerase chain reaction and restriction fragment length polymorphism were used to determine genotypes. Results - There was a significant difference in vitamin D receptor allele and genotype frequencies between the two groups. The allele B had a higher prevalence in patients with calcific aortic stenosis (B = 0.56, b = 0.44) than in the control cohort (B = 0.40, b = 0.60) (p = 0.001). Conclusions - There is a significant association of vitamin D receptor polymorphism with calcific aortic valve stenosis. The B allele of the vitamin D receptor is more common in patients with calcific aortic valve stenosis. It now needs to be evaluated whether other genes that control calcium homeostasis are involved in the pathogenesis of this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:34:35