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Titolo:
Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome
Autore:
Hewes, RS; Taghert, PH;
Indirizzi:
Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA
Titolo Testata:
GENOME RESEARCH
fascicolo: 6, volume: 11, anno: 2001,
pagine: 1126 - 1142
SICI:
1088-9051(200106)11:6<1126:NANRIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; LEUCOKININ-LIKE PEPTIDE; CENTRAL-NERVOUS-SYSTEM; BIOSYNTHESIS ACTIVATING NEUROPEPTIDE; CRUSTACEAN CARDIOACTIVE PEPTIDE; GALANIN BINDING-SITES; MOLECULAR-CLONING; DEVELOPMENTAL REGULATION; MANDUCA-SEXTA; SIGNALING PATHWAY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Hewes, RS Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 l, St Louis, MO 63110 USA
Citazione:
R.S. Hewes e P.H. Taghert, "Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome", GENOME RES, 11(6), 2001, pp. 1126-1142

Abstract

Recent genetic analyses in worms, flies, and mammals illustrate the importance of bioactive peptides in controlling numerous complex behaviors, such as feeding and circadian locomotion. To pursue a comprehensive genetic analysis of bioactive peptide signaling, we have scanned the recently completedDrosophila genome sequence for G protein-coupled receptors sensitive to bioactive peptides (peptide GPCRs). Here we describe 44 genes that represent the vast majority, and perhaps all, of the peptide GPCRs encoded in the flygenome. We also scanned for genes encoding potential ligands and describe 22 bioactive peptide precursors. At least 32 Drosophila peptide receptors appear to have evolved from common ancestors of 15 monophyletic vertebrate GPCR subgroups (e.g., the ancestral gastrin/ cholecystokinin receptor). Six pairs of receptors are paralogs, representing recent gene duplications. Together, these Findings shed light on the evolutionary history of peptide GPCRs, and they provide a template for physiological and genetic analyses of peptide signaling in Drosophila.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:22:09