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Titolo:
Evolutionary role of restriction modification systems as revealed by comparative genome analysis
Autore:
Rocha, EPC; Danchin, A; Viari, A;
Indirizzi:
Univ Paris 05, F-75005 Paris, France Univ Paris 05 Paris France F-75005Univ Paris 05, F-75005 Paris, France Inst Pasteur, Unite Regulat Express Genet, F-75724 Paris, France Inst Pasteur Paris France F-75724 t Express Genet, F-75724 Paris, France Univ Hong Kong, Pasteur Res Ctr, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China INRIA Rhone Alpes, F-38330 Montbonnot St Martin, France INRIA Rhone AlpesMontbonnot St Martin France F-38330 St Martin, France
Titolo Testata:
GENOME RESEARCH
fascicolo: 6, volume: 11, anno: 2001,
pagine: 946 - 958
SICI:
1088-9051(200106)11:6<946:ERORMS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORIZONTAL GENE-TRANSFER; ESCHERICHIA-COLI; BACTERIAL GENOMES; DNA-SEQUENCES; RECOGNITION SITES; BACILLUS-SUBTILIS; II RESTRICTION; PHAGE; SELECTION; ELEMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Rocha, EPC Univ Paris 05, F-75005 Paris, France Univ Paris 05 Paris France F-75005 05, F-75005 Paris, France
Citazione:
E.P.C. Rocha et al., "Evolutionary role of restriction modification systems as revealed by comparative genome analysis", GENOME RES, 11(6), 2001, pp. 946-958

Abstract

Type II restriction modification systems (RMSs) have been regarded either as defense tools or as molecular parasites of bacteria. We extensively analyzed their evolutionary role from the study of their impact in the completegenomes of 26 bacteria and 35 phages in terms of palindrome avoidance. This analysis reveals that palindrome avoidance is not universally spread among bacterial species and that it does not correlate with taxonomic proximity. Palindrome avoidance is also not universal among bacteriophage, even whentheir hosts code for RMSs, and depends strongly on the genetic material ofthe phage. Interestingly, palindrome avoidance is intimately correlated with the infective behavior of the phage. We observe that the degree of palindrome and restriction site avoidance is significantly and consistently lessimportant in phages than in their bacterial hosts. This result brings to the fore a larger selective load for palindrome and restriction site avoidance on the bacterial hosts than on their infecting phages. It is then consistent with a view where type II RMSs are considered as parasites possibly atthe verge of mutualism. As a consequence, RMSs constitute a nontrivial third player in the host-parasite relationship between bacteria and phages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:21:45