Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions
Autore:
Meza-Zepeda, LA; Berner, JM; Henriksen, J; South, AP; Pedeutour, F; Dahlberg, AB; Godager, LH; Nizetic, D; Forus, A; Myklebost, O;
Indirizzi:
Norwegian Radium Hosp, Inst Canc Res, Dept Tumor Biol, N-0310 Oslo, NorwayNorwegian Radium Hosp Oslo Norway N-0310 Tumor Biol, N-0310 Oslo, Norway Univ London, Sch Pharm, Ctr Appl Mol Biol, London WC1N 1AX, England Univ London London England WC1N 1AX l Mol Biol, London WC1N 1AX, England Hop Archet, Genet Lab, Nice, France Hop Archet Nice FranceHop Archet, Genet Lab, Nice, France
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 3, volume: 31, anno: 2001,
pagine: 264 - 273
SICI:
1045-2257(200107)31:3<264:ESFTHI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; PULMONARY CHONDROID HAMARTOMAS; IN-SITU HYBRIDIZATION; ADIPOSE-TISSUE TUMORS; HUMAN SARCOMAS; MOLECULAR CHARACTERIZATION; NEOPLASTIC TRANSFORMATION; UTERINE LEIOMYOMATA; MESENCHYMAL TUMORS; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Myklebost, O Norwegian Radium Hosp, Inst Canc Res, Dept Tumor Biol, N-0310Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 -0310 Oslo, Norway
Citazione:
L.A. Meza-Zepeda et al., "Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions", GENE CHROM, 31(3), 2001, pp. 264-273

Abstract

The HMGIC gene codes for an architectural transcription factor frequently rearranged by translocation in lipomas and other benign mesenchymal tumors. In sarcomas, malignant tumors of mesenchymal origin, the gene is also found to be rearranged, but in addition amplified and overexpressed. Here we report the sequence, chromosomal localization, and expression patterns of I Inovel ectopic sequences fused to exons 2 and 3 of HMGIC in seven differentsarcoma samples. In addition, we identified a number of variant transcripts observed previously in benign tumors. Consistent with the suggested role of HMGIC in adipocytic differentiation, most of the novel ectopic sequenceswere observed in well-differentiated liposarcomas. These tumors are known to have complex marker chromosomes containing amplified segments from several chromosomes. Five novel sequences were derived from 12q14-q15, where HMGIC resides, two from 1q24, a region frequently amplified in these types of tumors, two from 11q14, and one from chromosome 2. All except one of the aberrant transcripts encoded truncated proteins with intact DNA-binding domains (AT hooks) but lacking the C-terminal acidic region, a target, for constitutive phosphorylation by protein kinase CK2. Some of the ectopic sequences were transcribed in other tissues, and most of the ectopic sequences alsoshowed recurrent amplification in liposarcomas. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:28:35