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Titolo:
Occurrence of heterocyclic aromatic amines in the Swiss diet: analytical method, exposure estimation and risk assessment
Autore:
Zimmerli, B; Rhyn, P; Zoller, O; Schlatter, J;
Indirizzi:
Swiss Fed Off Publ Hlth, Div Food Sci, CH-3003 Bern, Switzerland Swiss FedOff Publ Hlth Bern Switzerland CH-3003 -3003 Bern, Switzerland
Titolo Testata:
FOOD ADDITIVES AND CONTAMINANTS
fascicolo: 6, volume: 18, anno: 2001,
pagine: 533 - 551
SICI:
0265-203X(200106)18:6<533:OOHAAI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; BOILED PORK JUICE; MEAT-PRODUCTS; COOKED FOODS; MUTAGENIC ACTIVITY; PAN RESIDUES; COLORECTAL-CANCER; COLON-CANCER; FRIED FOODS;
Keywords:
heterocyclic aromatic amines; analytical method; cooked meat; exposure; risk assessment; Switzerland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Zoller, O Swiss Fed Off Publ Hlth, Div Food Sci, CH-3003 Bern, SwitzerlandSwiss Fed Off Publ Hlth Bern Switzerland CH-3003 , Switzerland
Citazione:
B. Zimmerli et al., "Occurrence of heterocyclic aromatic amines in the Swiss diet: analytical method, exposure estimation and risk assessment", FOOD ADDIT, 18(6), 2001, pp. 533-551

Abstract

A total of 86 meat samples, prepared in restaurants or homes, ready to eat(including poultry and fish) and 16 commercial samples such as bouillon (cubes) were analysed for heterocyclic aromatic amines (HAA). The analytical method consisted of an acidic extraction, clean-up on a cation exchange cartridge followed by an analogous HPLC step to recover the following HAA: IQ,MeIQ, MeIQx, 4,8-DiMeIQx, PhIP and 7,8-DiMeIQx. The HAA containing HPLC-fractions were collected, the HAA identified and quantified using two RP-HPLC-systems of different retention properties (UV-detection). The limit of quantitation was in the range of 0.2-0.4 ng/g and the relative repeatability 6-15%. The recovery of PhIP was lower than for the other HAA analysed (less than 80%) and a correction factor was applied. No significant differences of the HAA-concentration were found in samples from homes and restaurants, half of the total samples contained HAA at the following frequencies: PhIP and MeIQx 33% (each), 4,8-DiMeIQx 11% and MeIQ 4%; 7,8-DiMeIQx and IQ were not detected. The frequencies in commercial products were for MeIQx 31%, 7,8-DiMeIQx 19%, IQ 13% and PhIP 6%: MeIQ and 4,8-DiMeIQx were not found. Based on these data, the average exposure of Swiss adults to HAA was estimated to be 5 ng/kg body mass per day, commercial products contributing less than10%. The theoretical excess cancer risk due to this intake was estimated on the base of the carcinogenic potency of the HAA in long-term animal experiments by linear extrapolation. The resulting risk in the order of 10(-4) at the maximum is discussed in terms of Swiss epidemiological data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:58:22