Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Sulindac in familial adenomatous polyposis: Evaluation by nuclear morphometry
Autore:
Fernandez-Lopez, F; Conde-Freire, R; Cadarso-Suarez, C; Garcia-Iglesias, J; Puente-Dominguez, JL; Potel-Lesquereux, J;
Indirizzi:
Univ Santiago de Compostela, Serv Cirugia Gral & Digest, Hosp Clin, Gen Surg Dept, ES-15706 Santiago De Compostela, Spain Univ Santiago de Compostela Santiago De Compostela Spain ES-15706 Spain Univ Santiago de Compostela, Serv Cirugia Gral & Digest, Hosp Clin, Dept Stat & Operat Res, ES-15706 Santiago De Compostela, Spain Univ Santiago de Compostela Santiago De Compostela Spain ES-15706 Spain
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
fascicolo: 5, volume: 167, anno: 2001,
pagine: 375 - 381
SICI:
1102-4151(200105)167:5<375:SIFAPE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; COLON-CANCER CELLS; COLORECTAL-CANCER; PROLIFERATION; APOPTOSIS; CHEMOPREVENTION; ADENOCARCINOMA; PRECURSORS; EXPRESSION; CARCINOMA;
Keywords:
FAP; morphometry; sulindac;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez-Lopez, F Univ Santiago de Compostela, Serv Cirugia Gral & Digest, Hosp Clin, Gen Surg Dept, 4A Planta,Choupana S-N, ES-15706 Santiago De Compostela, Spain Univ Santiago de Compostela 4A Planta,Choupana S-N SantiagoDe Compostela Spain ES-15706
Citazione:
F. Fernandez-Lopez et al., "Sulindac in familial adenomatous polyposis: Evaluation by nuclear morphometry", EURO J SURG, 167(5), 2001, pp. 375-381

Abstract

Objective: To find out if nuclear morphometry is a useful indicator of prognosis in patients with familial adenomatous polyposis (FAP) before and after treatment with sulindac. Design: Open study. Setting: Teaching hospital, Spain. Subjects: 29 patients (17 women and 12 men) with FAP who had been treated by colectomy. There were two control groups: 17 people with healthy rectal mucosa and 10 patients with colorectal cancer. Interventions: The 29 patients with FAP were treated with sulindac 150 mg orally twice daily for 6 months. Main outcome measures: Results of histological examination of biopsy specimens and nuclear morphometry. Results: Before treatment, all patients with FAP had nuclei of cells in the rectal mucosa that were intermediate in size between those in healthy mucosa (small nuclei) and those in cancer (large nuclei). After 6 months' treatment with sulindac the patients with FAP no longer had any polyps and the size of the nuclei was similar to those in healthy mucosa. Only 1 patient failed to respond, and in this patient one of the polyps subsequently becamemalignant. Conclusions: Nuclear morphometry may be useful in identifying patients with FAP who are at high risk of malignant degeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:34:27