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Titolo:
Effect of granulocyte-macrophage colony stimulating factor on bacterial translocation after experimental obstructive jaundice
Autore:
Unal, AE; Cevikel, MH; Ozgun, H; Tunger, A;
Indirizzi:
Adnan Menderes Univ, Dept Gen Surg, Sch Med, Aydin, Turkey Adnan Menderes Univ Aydin Turkey Dept Gen Surg, Sch Med, Aydin, Turkey Ege Univ, Sch Med, Dept Clin Microbiol, Izmir, Turkey Ege Univ Izmir Turkey Univ, Sch Med, Dept Clin Microbiol, Izmir, Turkey
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
fascicolo: 5, volume: 167, anno: 2001,
pagine: 366 - 370
SICI:
1102-4151(200105)167:5<366:EOGCSF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAILURE; RATS;
Keywords:
bacterial translocation; obstructive jaundice; granulocyte-macrophage colony stimulating factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Unal, AE Adnan Menderes Univ, Dept Gen Surg, Sch Med, Aydin, Turkey Adnan Menderes Univ Aydin Turkey Surg, Sch Med, Aydin, Turkey
Citazione:
A.E. Unal et al., "Effect of granulocyte-macrophage colony stimulating factor on bacterial translocation after experimental obstructive jaundice", EURO J SURG, 167(5), 2001, pp. 366-370

Abstract

Objective: To investigate the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on bacterial translocation promoted by obstructivejaundice. Design: Controlled animal study. Setting: University hospital, Turkey. Animals: 30 male Wistar albino rats. Interventions: The first group (n = 10) was the sham operation (control) group, and the second and the third (n = 10 each) had common bile duct (CBD)ligation and division under sterile conditions. The third group were also treated with GM-CSF 200 ng subcutaneously daily between the fifth and ninthpostoperative days. All animals were killed on the tenth day, and evaluated biochemically and histopathologically. Mesenteric lymph nodes were cultured under aerobic conditions. Main outcome measures: Biochemical analysis, histopathological evaluation, and aerobic cultures. Results: There was no bacterial translocation in either the control or GM-CSF groups, whereas Escherichia coli and Salmonella typhimurium were found in 4 and 2 animals, respectively in the ligation group. Although no aerobicbacteria was found in controls and the GM-CSF groups, bacterial translocation was 6/10 in the ligation alone group (p <0.01). Conclusion: Activation of inflammatory response with GM-CSF is highly effective in prevention of bacterial translocation in obstructive jaundice.

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Documento generato il 02/04/20 alle ore 02:12:05