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Titolo:
Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review
Autore:
Schoetzau, A; Gehring, U; Wichmann, HE;
Indirizzi:
GSF, Natl Res Ctr Environm & Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany GSF Neuherberg Germany D-85764 st Epidemiol, D-85764 Neuherberg, Germany Univ Munich, Inst Med Data Management Biometr & Epidemiol, Dept Epidemiol,Munich, Germany Univ Munich Munich Germany & Epidemiol, Dept Epidemiol,Munich, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PEDIATRICS
fascicolo: 6, volume: 160, anno: 2001,
pagine: 323 - 332
SICI:
0340-6199(200106)160:6<323:PCSUHF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-RISK INFANTS; PARTIAL WHEY HYDROLYSATE; COW MILK FORMULAS; CONTROLLED TRIALS; FOOD ALLERGY; FOLLOW-UP; DISEASE; MANIFESTATIONS; PROPHYLAXIS; AGE;
Keywords:
allergy prevention; hydrolysed formula; atopic disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Schoetzau, A GSF, Natl Res Ctr Environm & Hlth, Inst Epidemiol, Gebaude 56,IngolstadterLandstr 1, D-85764 Neuherberg, Germany GSF Gebaude 56,Ingolstadter Landstr 1 Neuherberg Germany D-85764
Citazione:
A. Schoetzau et al., "Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review", EUR J PED, 160(6), 2001, pp. 323-332

Abstract

The aim of this study is to give a systematic overview on publications having investigated the allergy preventive effect of extensively and/or partially hydrolysed infant formulas. Publications were searched by several strategies. Inclusion criteria were: prospective cohort study, randomisation, family history of atopy of the subjects, follow-up for at least the 1st year of life. Studies were described systematically as to methods, study participants, interventions and co-interventions, and study outcomes. The methodological quality was judged according to an instrument assessing the reduction of bias (score between 0 and 7 points). Data of studies having examined partial hydrolysates are presented as odds ratios. Of 16 studies found, 10 fulfilled the inclusion criteria. Study designs showed considerable differences as to methods, intervention and co-intervention procedures and definition of outcomes. Methodological quality varied between 0 and 6 points. The comparison of exclusively test- and control formula-fed groups showed a uniform tendency towards allergy protection in studies with partial hydrolysates. Study results on the effect of extensive hydrolysates were not comparable because of major differences in study designs. Conclusion More well-designed studies with an adequate statistical power are needed to compare the allergy preventive effect of partially and extensively hydrolysed formulas with a standard infant formula.

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Documento generato il 21/09/20 alle ore 15:20:24