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Titolo:
Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors
Autore:
Mezzano, D; Leighton, F; Martinez, C; Marshall, G; Cuevas, A; Castillo, O; Panes, O; Munoz, B; Perez, DD; Mizon, C; Rozowski, J; San Martin, A; Pereira, J;
Indirizzi:
Catholic Univ Chile, Sch Med, Haemostasis Lab, Dept Hematol Oncol, Santiago, Chile Catholic Univ Chile Santiago Chile Dept Hematol Oncol, Santiago, Chile Catholic Univ Chile, Sch Med, Biochem Cytol & Lipids Lab, Fac Biol Sci, Santiago, Chile Catholic Univ Chile Santiago Chile s Lab, Fac Biol Sci, Santiago, Chile Catholic Univ Chile, Sch Med, Dept Publ Hlth, Santiago, Chile Catholic Univ Chile Santiago Chile Med, Dept Publ Hlth, Santiago, Chile Catholic Univ Chile, Sch Med, Dept Nutr Diabet & Metab, Santiago, Chile Catholic Univ Chile Santiago Chile Nutr Diabet & Metab, Santiago, Chile
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 6, volume: 55, anno: 2001,
pagine: 444 - 451
SICI:
0954-3007(200106)55:6<444:CEOMDA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; COAGULATION-FACTOR-VII; ACTIVATOR INHIBITOR-1 GENE; FACTOR-V-LEIDEN; MYOCARDIAL-INFARCTION; PLASMINOGEN-ACTIVATOR; ALCOHOL-CONSUMPTION; INFLAMMATORY MARKERS; FIBRINOLYTIC FACTORS; BLOOD-COAGULATION;
Keywords:
diet; wine; haemostasis; cardiovascular risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Mezzano, D Catholic Univ Chile, Sch Med, Haemostasis Lab, Dept Hematol Oncol, POB 114-D, Santiago, Chile Catholic Univ Chile POB 114-D Santiago Chile Santiago, Chile
Citazione:
D. Mezzano et al., "Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors", EUR J CL N, 55(6), 2001, pp. 444-451

Abstract

Objectives: To compare the effect of alcohol-free Mediterranean-type diet (MDI and high-far diet (HFD) on plasma concentration of emergent haemostatic cardiovascular risk factors (HCVRF). Also, to test if red wine supplementation modifies HCVRF, independent of diet. Design, subjects and intervention: Controlled prospective intervention study. Two groups, each of 21 healthy male university students (22 +/-3.4 y), received either MD or HFD for 90 days. Between days 30 and 60, both diets were supplemented with 240 ml/day of red wine. Baseline and T30, T60 and T90-day samples were drawn. No drop out from the study was observed. Setting: University campus and outpatient nutrition clinic. Results: Volunteers on HFD at T30 had increases in pro-coagulants fibrinogen (22%), factor VIIc (9%), and factor VIIIc (4%), and decreases in naturalanticoagulants antithrombin III (3%), protein C (11%)and protein S (6%) and of 20% in plasminogen activator inhibitor-1. At the same time, individuals on MD had increases in fibrinogen (4%), antithrombin III (5%), protein C (3%), protein S (2.7%), and decreases in factor VIIIc (9%), and plasminogenactivator inhibitor-1 (21%). After adjusting by baseline values, MD was associated with lower plasma fibrinogen (P = 0.03), factor VIIc (P = 0.034) and factor VIIIc (P = 0.0057) and with higher levels of protein S (P = 0.013). Red wine supplementation, in both diets, resulted in decreased plasma fibrinogen (P = 0.001) and factor VIIc (P = 0.05), and increased tissue plasminogen activator antigen (P=0.01) and plasminogen activator inhibitor-1 antigen (P = 0.0003). Wine consumption was also associated with significantly (P = 0.01) divergent effects on antithrombin III: it decreased by 10% in individuals on HFD but increased slightly in those on MD. No effects of diet or wine were detected in plasma protein C and C-reactive protein. Conclusion: MD and moderate consumption of red wine have complementary, mostly beneficial effects on HCVRF. Sponsorship: P Catholic University of Chile.

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Documento generato il 05/12/20 alle ore 23:58:39