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Titolo:
Chronic beta-blocker therapy improves outcome and reduces treatment costs in chronic type B aortic dissection
Autore:
Genoni, M; Paul, M; Jenni, R; Graves, K; Seifert, B; Turina, M;
Indirizzi:
Univ Zurich Hosp, Div Cardiac Surg, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Div Echocardiog, CH-8091 Zurich, Switzerland Univ ZurichHosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich, Dept Biostat ISPM, Zurich, Switzerland Univ Zurich Zurich Switzerland , Dept Biostat ISPM, Zurich, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 5, volume: 19, anno: 2001,
pagine: 606 - 610
SICI:
1010-7940(200105)19:5<606:CBTIOA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARFAN-SYNDROME; ADRENERGIC-BLOCKADE; ANEURYSMS; RUPTURE;
Keywords:
aortic dissection; antihypertensive agent; beta-blocker; cost of treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Genoni, M Triemli City Hosp, Dept Heart Surg, Birmensdorferstr 397, CH-8063 Zurich, Switzerland Triemli City Hosp Birmensdorferstr 397 Zurich Switzerland CH-8063
Citazione:
M. Genoni et al., "Chronic beta-blocker therapy improves outcome and reduces treatment costs in chronic type B aortic dissection", EUR J CAR-T, 19(5), 2001, pp. 606-610

Abstract

Objectives: To compare the medical treatment of chronic type B aortic dissection with beta -blockers versus other antihypertensive treatments in terms of their requirement for surgical intervention and treatment costs. Methods: Case records of the 130 patients treated for aortic dissection type B in this unit between 1988 and 1997 were reviewed. Seventy-eight of 130 patients with chronic dissection have received isolated medical treatment. Seventy-one of 78 patients were discharged alive. Fifty-one of 71 received beta -blocker treatment, 20/71 were treated with other antihypertensive drugs. Results: Surgery for aortic dissection became necessary in 20/71 patients (28%) during follow-up (mean, 4.2 years): 10/51 in the beta -blocker group and 9/20 in the other antihypertensive drug group. The freedom from subsequent aortic operation was 80 and 47%, respectively (P = 0.001). Indications for emergency surgery were increased aortic diameter (79%), symptomatic aortic aneurysm (11%), and renal artery hypoperfusion (5%). The median hospitalization time during follow-up (dissection-related) was 2 days for patients who received beta -blockers and 16 days for patients who received other antihypertensive drug treatments (P = 0.001). The cost of treatment/patient peryear amounted to 644 and 12 748 euros, respectively. Conclusions: A substantial proportion of patients with chronic type B dissection who receive initial medical management will later need surgery. Long-term treatment with beta -blockers reduces the progression of aortic dilatation, the incidence of subsequent hospital admissions, as well as the incidence of late dissection-related aortic procedures and the cost of treatment. Patients with chronic type B dissection need, in addition to frequent follow-up of aortic diameter, continuous treatment with beta -blocking agents. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:56:49