Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of retigabine on rhythmic synchronous activity of human neocortical slices
Autore:
Straub, H; Kohling, R; Hohling, JM; Rundfeldt, C; Tuxhorn, I; Ebner, A; Wolf, P; Pannek, H; Speckmann, EJ;
Indirizzi:
Univ Munster, Inst Physiol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 t Physiol, D-48149 Munster, Germany Univ Munster, Inst Expt Epilepsieforsch, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 sieforsch, D-48149 Munster, Germany ASTA Medica Grp, Corp R&D, Dept Pharmacol, D-01445 Radebeul, Germany ASTA Medica Grp Radebeul Germany D-01445 acol, D-01445 Radebeul, Germany Krankenanstalten Gilead, Neurochirurg Klin, D-33167 Bielefeld, Germany Krankenanstalten Gilead Bielefeld Germany D-33167 167 Bielefeld, Germany Fachkrankenhaus Mara 1, Epilepsiezentrum Bethel, D-33167 Bielefeld, Germany Fachkrankenhaus Mara 1 Bielefeld Germany D-33167 3167 Bielefeld, Germany
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2-3, volume: 44, anno: 2001,
pagine: 155 - 165
SICI:
0920-1211(200105)44:2-3<155:EORORS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED EPILEPTIFORM ACTIVITY; LOW EXTRACELLULAR MAGNESIUM; CORTEX HIPPOCAMPAL SLICES; SPONTANEOUS SHARP WAVES; ANTICONVULSANT RETIGABINE; MAINTAINED INVITRO; IN-VITRO; DIFFERENT PATTERNS; K+ CHANNELS; D-23129;
Keywords:
human slice; spontaneous sharp waves; low-Mg2+; bicuculline; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Straub, H Univ Munster, Inst Physiol, Robert Koch Str 27A, D-48149 Munster, Germany Univ Munster Robert Koch Str 27A Munster Germany D-48149 ermany
Citazione:
H. Straub et al., "Effects of retigabine on rhythmic synchronous activity of human neocortical slices", EPILEPSY R, 44(2-3), 2001, pp. 155-165

Abstract

The antiepileptic effects of the novel antiepileptic,drug retigabine (D-23129) [N-(2-amino-4-(4-flurobenzylamino)phenyl) carbamid acid ethyl ester] were tested in neocortical slice preparations (n = 23) from 17 patients (age, 3-42 years) who underwent surgery for the treatment of intractable epilepsy. Epileptiform events consisted of spontaneously occurring rhythmic sharpwaves, as well as of epileptiform field potentials (EFP) elicited by superfusion with Mg2+-free solution without or with addition of 10 mu mol/l bicuculline. (1) Spontaneous rhythmic sharp waves (n = 6), with retigabine application, the repetition rate was decreased down to 12-47% of initial value (10 mu mol/l, n = 3) after 180 min or suppressed completely within 12 min (50 mu mol/l, n = 3). (2) Low Mg2+ EFP (n = 9), with retigabine application,the repetition rate was decreased down to 50 and 65% of initial value (10 mu mol/l; n = 2) after 180 min or suppressed completely after 9-55 min (10,50 and 100 mu mol/l; n = 2 in each case). In one slice only a transient reduction of the repetition rate was seen with 10 mu mol/l retigabine. (3) Low Mg2+ EFP with addition of bicuculline (n = 8), with retigabine application, the repetition rate was decreased down to 12-55% of initial value (10 mumol/l; n = 4) after 180 min or suppressed completely after 6-30 min (50 and 100 mu mol/l; n = 2 in each case). The depressive effect of retigabine was reversible in all but one slice. The results show a Clear antiepileptic effect of retigabine in human neocortical slices on spontaneously occurring rhythmic sharp waves and different types of induced seizure activity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:58:58