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Titolo:
Effects of chronic morphine and N-6-cyclopentyl-adenosine administration on kainic acid-induced status epilepticus
Autore:
Cano-Martinez, A; Villalobos-Molina, R; Rocha, L;
Indirizzi:
Inst Nacl Psiquiatria Ramon de la Fuente, Mexico City 14370, DF, Mexico Inst Nacl Psiquiatria Ramon de la Fuente Mexico City DF Mexico 14370 xico Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico 14080 , DF, Mexico IPN, Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Mexico City 14330,DF, Mexico IPN Mexico City DF Mexico 14330 Farmacobiol, Mexico City 14330,DF, Mexico
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2-3, volume: 44, anno: 2001,
pagine: 89 - 96
SICI:
0920-1211(200105)44:2-3<89:EOCMAN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC NALOXONE PRETREATMENT; KINDLED AMYGDALOID SEIZURES; OPIOID RECEPTOR-BINDING; A1 ADENOSINE RECEPTORS; TEMPORAL-LOBE EPILEPSY; RAT HIPPOCAMPUS; ELECTROCONVULSIVE SHOCK; TREATMENT INCREASES; POSTICTAL EVENTS; OPIATE BINDING;
Keywords:
kainic acid; mu receptors; Al receptors; status epilepticus; opioid peptides; adenosine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Rocha, L Inst Nacl Psiquiatria Ramon de la Fuente, Av Mexico Xochimilco 101, MexicoCity 14370, DF, Mexico Inst Nacl Psiquiatria Ramon de la Fuente AvMexico Xochimilco 101 Mexico City DF Mexico 14370
Citazione:
A. Cano-Martinez et al., "Effects of chronic morphine and N-6-cyclopentyl-adenosine administration on kainic acid-induced status epilepticus", EPILEPSY R, 44(2-3), 2001, pp. 89-96

Abstract

The aim of the present study was to investigate if the upregulation of mu or A(1) receptors modifies the expression of the kainic acid (KA)-induced status epilepticus (SE). Male Wistar rats received one of the following treatments: saline solution (SS) (1 ml/kg, i.p. for 7 days); morphine (M) (20 mg/kg, i.p. for 7 days) or N-6-cyclopentyl-adenosine (CPA) (1 mg/kg, i.p. for 9 days). Twenty-four hours after the last administration rats were sacrificed. Membranes were obtained mu and and A(1) receptor binding experiments were carried out. Furthermore, an injection of SS (1 ml/kg, i.p.) or KA (10mg/kg, i.p.) was applied in rats pretreated chronically with M, CPA or SS,48 h after the last administration. Seizure activity, death rate and a postictal explosive motor behavior were evaluated after KA administration. Chronic M administration increased mu receptor number in hippocampus (115%) and cortex (265%), whereas chronic CPA treatment enhanced A(1) receptor number in hippocampus (55%), amygdala (39%) and cortex (51%). The pretreatment with M facilitated the KA-induced SE and reduced the death rate as well as the postictal explosive motor behavior. The pretreatment with CPA delayed the SE presentation, increased the death rate and decreased the postictal explosive motor behavior. These findings suggest that upregulation of mu receptors enhances the KA seizures, whereas upregulation of A(1) receptors depresses these seizures. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:17:11