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Titolo:
Morphogenetic cell movements in the middle region of the dermomyotome dorsomedial lip associated with patterning and growth of the primary epaxial myotome
Autore:
Denetclaw, WF; Berdougo, E; Venters, SJ; Ordahl, CP;
Indirizzi:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Inst Cardiovasc Res, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 10, volume: 128, anno: 2001,
pagine: 1745 - 1755
SICI:
0950-1991(200105)128:10<1745:MCMITM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
XENOPUS-LAEVIS; SOMITE; MOUSE; EMBRYOS; ORIGIN;
Keywords:
muscle; morphogenesis; DiI; DiO; somite; involution; dermomyotome; confocal microscopy; fate mapping; chick;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ordahl, CP San Francisco State Univ, Dept Biol, San Francisco, CA 94132 USA San Francisco State Univ San Francisco CA USA 94132 94132 USA
Citazione:
W.F. Denetclaw et al., "Morphogenetic cell movements in the middle region of the dermomyotome dorsomedial lip associated with patterning and growth of the primary epaxial myotome", DEVELOPMENT, 128(10), 2001, pp. 1745-1755

Abstract

The morphogenetic cell movements responsible for growth and morphogenesis in vertebrate embryos are poorly understood, Myotome precursor cells undergo myotomal translocation; a key morphogenetic cell movement whereby myotomal precursor cells leave the dermomyotome epithelium and enter the subjacentmyotome layer where myogenic differentiation ensues. The precursors to theembryonic epaxial myotome are concentrated in the dorsomedial lip (DML) ofthe somite dermomyotome (W. F. Denetclaw, B. Christ and C, P, Ordahl (1997) Development 124, 1601-1610), a finding recently substantiated through surgical transplantation studies (C. P. Ordahl, E. Berdougo, S, J. Venters andW. F.Denetclaw, Jr (2001) Development 128, 1731-1744). Confocal microscopywas used here to analyze the location and pattern of myotome cells whose precursors had earlier been labeled by fluorescent dye injection into the middle region of the DML, a site that maximizes the potential to discriminateamong experimental outcomes. Double-dye injection experiments conducted atthis site demonstrate that cells fated to form myotome do not involute around the recurved epithelium of the DML but rather are displaced laterally where they transiently intermingle with cells fated to enter the central epithelial sheet region of the dermomyotome. Time- and position-dependent labeling experiments demonstrated that myotome precursor cells translocate directly from the middle region of the DML without prior intra-epithelial 'translational' movements of precursor cells to either the cranial or caudal lips of the dermomyotome epithelium, nor were any such translational movementsevident in these experiments. The morphogenetic cell movements demonstrated here to be involved in the directional growth and segmental patterning ofthe myotome and dermomyotome bear interesting similarities with those of other morphogenetic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:35:48