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Titolo:
Microdialysis can detect age-related differences in glucose distribution within the dermis and subcutaneous adipose tissue
Autore:
Boschmann, M; Murphy, FP; Krueger, JG;
Indirizzi:
German Inst Human Nutr, Potsdam, Germany German Inst Human Nutr Potsdam Germany nst Human Nutr, Potsdam, Germany Rockefeller Univ Hosp, New York, NY 10021 USA Rockefeller Univ Hosp New York NY USA 10021 Hosp, New York, NY 10021 USA
Titolo Testata:
DERMATOLOGY
fascicolo: 3, volume: 202, anno: 2001,
pagine: 207 - 210
SICI:
1018-8665(2001)202:3<207:MCDADI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN BLOOD-FLOW; CADAVER SKIN; GLYCEROL; METABOLISM; WATER; ASSAY;
Keywords:
aging; glucose; glycerol; nutrition; skin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Boschmann, M German Inst Human Nutr, Dept Biochem & Physiol Nutr, Arthur Scheunert Allee 114-116, D-14558 Bergholz Rehbrucke, Germany German Inst Human Nutr Arthur Scheunert Allee 114-116 Bergholz Rehbrucke Germany D-14558
Citazione:
M. Boschmann et al., "Microdialysis can detect age-related differences in glucose distribution within the dermis and subcutaneous adipose tissue", DERMATOLOGY, 202(3), 2001, pp. 207-210

Abstract

Background: Intrinsic (chronological) cutaneous aging is a continuous and complex process. Limitation in nutrient supply to the skin could contributeto this process. Objective: Our study focused on the impact of age on glucose supply to human skin and its distribution within the dermis and subcutaneous adipose tissue. Methods: An oral glucose load (100 g) was given to healthy volunteers of two age groups (24 +/- 4 and 59 +/- 10 years, n = 4 foreach group). Dialysate concentrations of glucose and glycerol were monitored by microdialysis in the dermis and adipose tissue. Results: Baseline tissue [glucose] did not differ significantly between the two groups. After the glucose load, dialysate [glucose] of the dermis peaked between 60 and 80 min and between 80 and 120 min in the young and old groups, respectively. In the old group, dialysate [glucose] was significantly higher in the dermisthan adipose tissue at 80, 100, 120, 160 and 180 min after the load. The sum of the areas under the curve (dermis + adipose tissue) did not differ significantly between the two age groups. Conclusions: Aging is accompanied by an increased diffusion barrier for glucose between the dermis and adiposetissue. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:55:52