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Titolo:
The genetic basis of endometriosis
Autore:
Zondervan, KT; Cardon, LR; Kennedy, SH;
Indirizzi:
Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England Wellcome Trust CtrHuman Genet Oxford England OX3 7BN d OX3 7BN, England John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU ecol, Oxford OX3 9DU, England
Titolo Testata:
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 309 - 314
SICI:
1040-872X(200106)13:3<309:TGBOE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSE-1-PHOSPHATE URIDYL TRANSFERASE; STROMAL CELLS; CANCER SUSCEPTIBILITY; OVARIAN ENDOMETRIOSIS; CIGARETTE-SMOKING; GROWTH-FACTOR; LUNG-CANCER; EXPRESSION; RECEPTOR; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Zondervan, KT Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England Wellcome Trust Ctr Human Genet Roosevelt Dr Oxford England OX3 7BN
Citazione:
K.T. Zondervan et al., "The genetic basis of endometriosis", CUR OP OBST, 13(3), 2001, pp. 309-314

Abstract

Family studies have long suggested a role for genetic factors in the aetiology of endometriosis. The influence of genes on disease development has mainly been researched independently of environmental factors, yet their interaction must play an important role. Greater exposure to retrograde menstruation and oestrogen is likely to increase the risk of endometriosis; toxic compounds such as dioxin may increase the risk, although the only direct evidence has come from primate studies. Previous association studies implicated GALT (a gene involved in galactose metabolism), and GSTM1 and NAT2 (genes encoding for the detoxification enzymes) as possible disease susceptibility genes. Recent findings have added to the evidence for the involvement ofGSTM1 and NAT2, but have cast doubt on the role of GALT. However, the design of many genetic and epidemiological studies has been inadequate with respect to sample size, consistency in phenotype definition, and the choice ofcontrol populations. These features are likely to influence results, and could partly explain the lack of consistency in the findings. Future studiesshould use a consistent disease definition and be of appropriate epidemiological design. Curr Opin Obstet Gynecol 13:309-314. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 07:29:53