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Titolo:
Cytokines and chemokines in the immune response to hepatitis C infection
Autore:
Heydtmann, M; Shields, P; McCaughan, G; Adams, D;
Indirizzi:
Univ Birmingham, Queen Elizabeth Med Ctr, Liver Res Labs, Birmingham B15 2TH, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TH W Midlands, England
Titolo Testata:
CURRENT OPINION IN INFECTIOUS DISEASES
fascicolo: 3, volume: 14, anno: 2001,
pagine: 279 - 287
SICI:
0951-7375(200106)14:3<279:CACITI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
IFN-INDUCIBLE PROTEIN-10; CD8(+) T-CELLS; MONOCYTE CHEMOTACTIC PROTEIN-1; VIRUS CORE PROTEIN; PERIPHERAL-BLOOD; STELLATE CELLS; LIVER-INJURY; CHRONIC INFLAMMATION; ALLOGRAFT-REJECTION; ANTIVIRAL DEFENSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Adams, D Univ Birmingham, Queen Elizabeth Med Ctr, Liver Res Labs, Birmingham B15 2TH, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TH s, England
Citazione:
M. Heydtmann et al., "Cytokines and chemokines in the immune response to hepatitis C infection", CURR OPIN I, 14(3), 2001, pp. 279-287

Abstract

Over 170 million people are infected with the hepatitis C virus worldwide,resulting in a large disease burden and significant mortality. Hepatitis Cvirus is rarely cleared in the acute phase of the infection and most patients become chronically infected; a proportion of these patients develop progressive liver disease and fibrosis. The outcome of infection depends on the immune responses of both the innate and cognate immune systems, and thesein turn are orchestrated by networks of cytokines and chemokines, There isevidence that a vigorous type 1 immune response to viral proteins is required for viral elimination, and the recruitment of such effector cells to the liver is dependent on the local activity of specific inducible chemokines. Multiple factors determine the ability of the hepatitis C virus to survive host immune responses, including an ability to alter the cytokine profilesecreted by T cells and to cause resistance to the effects of antiviral cytokines such as interferon, In the present review, we briefly cover the important advances made in this area over the past 12 months. Curr Opin InfectDis 14:279-287. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:21:42