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Titolo:
Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection
Autore:
Yoshikai, Y;
Indirizzi:
Nagoya Univ, Sch Med, Res Inst Dis Mech & Control, Lab Host Dev & GermfreeLife, Nagoya, Aichi 466, Japan Nagoya Univ Nagoya Aichi Japan 466 GermfreeLife, Nagoya, Aichi 466, Japan
Titolo Testata:
CURRENT OPINION IN INFECTIOUS DISEASES
fascicolo: 3, volume: 14, anno: 2001,
pagine: 257 - 263
SICI:
0951-7375(200106)14:3<257:ROPALI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI INFECTION; PPAR-GAMMA AGONISTS; PROTEIN-KINASE-A; KAPPA-B KINASE; 5-LIPOXYGENASE-ACTIVATING PROTEIN; DEFICIENT MICE; B-4 RECEPTOR; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); CYCLOPENTENONE PROSTAGLANDINS; CYSTEINYL LEUKOTRIENES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshikai, Y Nagoya Univ, Sch Med, Host Def Lab, Res Inst Dis Mech & Control,Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsurumai Cho Nagoya Aichi Japan 4668550 , Japan
Citazione:
Y. Yoshikai, "Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection", CURR OPIN I, 14(3), 2001, pp. 257-263

Abstract

Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A(2)/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid. At physiological concentrations, vasodilator prostaglandins enhance the vascular permeability effects of histamine and bradykinin, and leukotrienes are important mediators of leukocyte accumulation during acute inflammation. On the other hand, prostaglandin metabolites such as cyclopentenone prostaglandins contribute to the resolution of acute inflammation through inhibition of nuclear factor-chiB activation. Thus, arachidonic acid oxygenation products mediate diverse effects that induce and resolve acute inflammation caused by bacterial infection. Curr Opin Infect Dis 14:257-263. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:04:47