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Titolo:
The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases
Autore:
Goedert, M;
Indirizzi:
MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH , Mol Biol Lab, Cambridge CB2 2QH, England
Titolo Testata:
CURRENT OPINION IN GENETICS & DEVELOPMENT
fascicolo: 3, volume: 11, anno: 2001,
pagine: 343 - 351
SICI:
0959-437X(200106)11:3<343:TSOTAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; GLIAL CYTOPLASMIC INCLUSIONS; INHERITED DEMENTIA FTDP-17; CORTICAL LEWY BODIES; PARKINSONS-DISEASE; FRONTOTEMPORAL DEMENTIA; TRANSGENIC MICE; IN-VITRO; ALZHEIMERS-DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Goedert, M MRC, Mol Biol Lab, Hills Rd, Cambridge CB2 2QH, England MRC Hills Rd Cambridge England CB2 2QH bridge CB2 2QH, England
Citazione:
M. Goedert, "The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases", CUR OP GEN, 11(3), 2001, pp. 343-351

Abstract

Intracellular filamentous inclusions made of either the microtubule-associated protein tau or the protein alpha -synuclein define the majority of cases of neurodegenerative disease. Mutations in the tau gene in familial forms of frontotemporal dementia and in the alpha -synuclein gene in familial cases of Parkinson's disease have provided causal links between the dysfunction of these proteins and neurodegeneration. Over the past year, several novel tau gene mutations have been identified and more has been learned aboutpossible mechanisms by which tau gene mutations lead to frontotemporal dementia. Experimental animal models have provided a link between tau filamentformation and nerve cell degeneration. Along similar lines, animal models have been produced that result in the formation of alpha -synuclein filaments and the degeneration of dopaminergic nerve cells. Building on previous work, synthetic alpha -synuclein filaments have been shown to exhibit the characteristics of amyloid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:12:56