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Titolo:
Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression
Autore:
Sestan, N; Rakic, P; Donoghue, MJ;
Indirizzi:
Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Neurobiol Sect, New Haven, CT 06510 USA
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 39 - 43
SICI:
0960-9822(20010109)11:1<39:IPOTEV>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE CEREBRAL-CORTEX; RHESUS-MONKEY; EPH RECEPTORS; PROJECTIONS; CONNECTIONS; EPHRIN-A5; LIGAND; SYSTEM; AXONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Donoghue, MJ Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ct, New Haven, CT 06510 USA
Citazione:
N. Sestan et al., "Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression", CURR BIOL, 11(1), 2001, pp. 39-43

Abstract

The visual cortex in primates is parcellated into cytoarchitectonically, physiologically, and connectionally distinct areas: the striate cortex (V1) and the extrastriate cortex, consisting of V2 and numerous higher association areas [1], The innervation of distinct visual cortical areas by the thalamus is especially segregated in primates, such that the lateral geniculate(LG) nucleus specifically innervates striate cortex, whereas pulvinar projections are confined to extrastriate cortex [2-8], The molecular bases for the parcellation of the visual cortex and thalamus, as well as the establishment of reciprocal connections between distinct compartments within these two structures, are largely unknown, Here, we show that prospective visual cortical areas and corresponding thalamic nuclei in the embryonic rhesus monkey (Macaca mulatta) can be defined by combinatorial expression of genes encoding Eph receptor tyrosine kinases and their ligands, the ephrins, priorto obvious cytoarchitectonic differentiation within the cortical plate andbefore the establishment of reciprocal connections between the cortical plate and thalamus, These results indicate that molecular patterns of presumptive visual compartments in both the cortex and thalamus can form independently of one another and suggest a role for EphA family members in both compartment formation and axon guidance within the visual thalamocortical system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:04:41