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Titolo:
eat-11 encodes GPB-2, a G beta(5) ortholog that interacts with G(o)alpha and G(q)alpha to regulate C-elegans behavior
Autore:
Robatzek, M; Niacaris, T; Steger, K; Avery, L; Thomas, JH;
Indirizzi:
Univ Washington, Dept Genet, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 n, Dept Genet, Seattle, WA 98195 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 d Ctr, Dept Mol Biol, Dallas, TX 75390 USA
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 4, volume: 11, anno: 2001,
pagine: 288 - 293
SICI:
0960-9822(20010220)11:4<288:EEGAGB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAENORHABDITIS-ELEGANS; SYNAPTIC TRANSMISSION; KINASE-II; MUTATIONS; DIACYLGLYCEROL; PROTEINS; SUBUNIT; BINDING; RELEASE; DOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, JH Univ Washington, Dept Genet, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 et, Seattle, WA 98195 USA
Citazione:
M. Robatzek et al., "eat-11 encodes GPB-2, a G beta(5) ortholog that interacts with G(o)alpha and G(q)alpha to regulate C-elegans behavior", CURR BIOL, 11(4), 2001, pp. 288-293

Abstract

In C. elegans, a G(o)/G(q) signaling network regulates locomotion and egg laying [1-8], Genetic analysis shows that activated Ca2+/calmodulin-dependent protein kinase II (CaMKII) is suppressed by perturbations of this network, which include loss of the GOA-1 G(o)alpha, DGK-1 diacylglycerol kinase, EAT-16 16 protein gamma subunit-like (GGL)-containing RGS protein, or an unidentified protein encoded by the gene eat-11 [9], We cloned eat-11 and report that it encodes the G beta (5) ortholog GPB-2, Gp, binds specifically to GGL-containing RGS proteins, and the G beta (5)/RGS complex can promote the GTP-hydrolyzing activity of G alpha subunits [10, 11], However, little is known about how this interaction affects G protein signaling in vivo. In addition to EAT-16, the GGL-containing RGS protein EGL-10 participates in G(o)/G(q) signaling; EGL-10 appears to act as an RGS for the GOA-1 G,cw, while EAT-16 appears to act as an RGS for the EGL-30 G(q)alpha [4, 5], We havecombined behavioral, electrophysiological, and pharmacological approaches to show that GPB-2 is a central member of the G(o)/G(q) network and that GPB-2 may interact with both the EGL-10 and EAT-16 RGS proteins to mediate the opposing activities of G,cw and G,a. These interactions provide a mechanism for the modulation of behavior by antagonistic G protein networks.

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Documento generato il 03/04/20 alle ore 04:23:10