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Titolo:
Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye
Autore:
Li, YX; Baker, NE;
Indirizzi:
Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 ol Genet, Bronx, NY 10461 USA
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 330 - 338
SICI:
0960-9822(20010306)11:5<330:PEBNOS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; ORGAN DEVELOPMENT; EXPRESSING CELLS; GENETIC MOSAICS; NUCLEAR ACCESS; DELTA; COMPLEX; NEUROGENESIS; RECEPTOR; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, NE Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Bronx, NY 10461 USA
Citazione:
Y.X. Li e N.E. Baker, "Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye", CURR BIOL, 11(5), 2001, pp. 330-338

Abstract

Background: The receptor protein Notch plays a conserved role in restricting neural-fate specification during lateral inhibition. Lateral inhibition requires the Notch intracellular domain to coactivate Su(H)mediated transcription of the Enhancer-of-split Complex. During Drosophila eye development,Notch plays an additional role in promoting neural fate independently of Su(H) and E(spl)-C, and this finding suggests an alternative mechanism of Notch signal transduction. Results: We used genetic mosaics to analyze the proneural enhancement pathway, As in lateral inhibition, the metalloprotease Kuzbanian, the EGF repeat 12 region of the Notch extracellular domain, Presenilin, and the Notch intracellular domain were required. By contrast, proneural enhancement becameconstitutive in the absence of Su(H), and this led to premature differentiation and upregulation of the Atonal and Senseless proteins. Ectopic Notch signaling by Delta expression ahead of the morphogenetic furrow also causedpremature differentiation. Conclusions: Proneural enhancement and lateral inhibition use similar ligand binding and receptor processing but differ in the nuclear role of Su(H). Prior to Notch signaling, Su(H) represses neural development directly, notindirectly through E(spl)-C. During proneural enhancement, the Notch intracellular domain overcomes the repression of neural differentiation. Later, lateral inhibition restores the repression of neural development by a different mechanism, requiring E(spl)-C transcription. Thus, Notch restricts neurogenesis temporally to a narrow time interval between two modes of repression. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:11:24