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Titolo:
Mutual information analysis of the EEG in patients with Alzheimer's disease
Autore:
Jeong, J; Gore, JC; Peterson, BS;
Indirizzi:
Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Diagnost Radiol, New Haven, CT 06520 USA Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Ctr Child Study, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Diagnost Radiol & Appl Phys, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 iol & Appl Phys, New Haven, CT 06520 USA
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 5, volume: 112, anno: 2001,
pagine: 827 - 835
SICI:
1388-2457(200105)112:5<827:MIAOTE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENILE DEMENTIA; CEREBRAL-CORTEX; TIME-SERIES; COHERENCE; DISTRIBUTIONS; DIAGNOSIS; THALAMUS; LAMINAR; PLAQUES; NUCLEI;
Keywords:
information transmission; EEG; mutual information; Alzheimer's disease; functional connectivity; complexity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Jeong, J Korea Univ, Dept Phys, Sungbuk Gu, Anham Dong 5-1, Seoul 136701, South Korea Korea Univ Anham Dong 5-1 Seoul South Korea 136701 , South Korea
Citazione:
J. Jeong et al., "Mutual information analysis of the EEG in patients with Alzheimer's disease", CLIN NEU, 112(5), 2001, pp. 827-835

Abstract

Objective: Mutual information provides a measure of both the linear and nonlinear statistical dependencies between two time series. Cross-mutual information (CMI) is used to quantify the information transmitted from one timeseries to another, while auto mutual information (AMI) in a time series estimates how much on average the value of the time series can be predicted from values of the time series at preceding points. The aim of this study isto assess information transmission between different cortical areas in Alzheimer's disease (AD) patients by estimating the average CMI between EEG electrodes. Methods: We recorded the EEG from 16 scale electrodes in 15 AD patients and 15 age-matched normal controls, and estimated the local, distant, and interhemispheric CMIs of the EEG in both groups. The rate of decrease (with increasing delay) of the AMI of the EEG was also measured to evaluate the complexity of the EEG in AD patients. Results: The local CMI in AD subjects was lower than that in normal controls, especially over frontal and antero-temporal regions. A prominent decrease in information transmission between distant electrodes in the right hemisphere and between corresponding interhemispheric electrodes was detected in the AD patients. In addition, the AMIs throughout the cerebrums of the ADpatients decreased significantly more slowly with delay than did the AMIs of normal controls. Conclusions: These results are consistent with previous findings that suggest the association of EEG abnormalities in AD patients with functional impairment of information transmission in long cortico-cortical connections. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:04:08